Cohen Lorenzo, de Moor Carl, Parker Patricia A, Amato Robert J
Department of Behavioral Science, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 243, Houston, TX 77030, USA.
Urol Oncol. 2002 May-Jun;7(3):119-24. doi: 10.1016/s1078-1439(01)00182-x.
We prospectively examined quality of life (QOL) in patients with metastatic renal cell carcinoma treated with nephrectomy followed by heat shock protein peptide complex 96 (HSPPC-96) vaccine, a nontoxic, active, specific immunotherapy.
QOL and intrusive thoughts were measured in 36 patients with newly diagnosed stage IV renal cell carcinoma at the start of treatment, 3 weeks later on the final day of treatment, and at follow-up 1 month later. At each assessment, patients completed the RAND 36-Item Health Survey and the Impact of Event Scale (IES).
Mixed model analyses revealed a significant improvement over time in the Physical Component Summary score (p < 0.0001) and no significant change over time in the Mental Component Summary score or the IES scores. In comparisons with other populations, at the 1-month follow-up assessment, patients reported significantly worse QOL than the general population on the physical dimensions and similar QOL on the psychosocial and emotional dimensions, a similar QOL to that in patients with type II diabetes, and a significantly better QOL on four dimensions than that in patients with congestive heart failure.
QOL remained stable or improved during treatment with the HSPPC-96 vaccine.
我们前瞻性地研究了接受肾切除术后再使用热休克蛋白肽复合物96（HSPPC - 96）疫苗治疗的转移性肾细胞癌患者的生活质量（QOL），HSPPC - 96疫苗是一种无毒、活性、特异性免疫疗法。
在36例新诊断为IV期肾细胞癌的患者治疗开始时、治疗3周后（治疗最后一天）以及1个月后的随访中测量其生活质量和侵入性思维。每次评估时，患者完成兰德36项健康调查和事件影响量表（IES）。
混合模型分析显示，身体成分总结得分随时间有显著改善（p < 0.0001），而心理成分总结得分或IES得分随时间无显著变化。与其他人群相比，在1个月的随访评估中，患者在身体维度上报告的生活质量显著低于一般人群，在心理社会和情感维度上生活质量相似，与II型糖尿病患者的生活质量相似，在四个维度上的生活质量显著优于充血性心力衰竭患者。
使用HSPPC - 96疫苗治疗期间，生活质量保持稳定或有所改善。
