Kolsteren Evie E M, Deuning-Smit Esther, Chu Alanna K, van der Hoeven Yvonne C W, Prins Judith B, van der Graaf Winette T A, van Herpen Carla M L, van Oort Inge M, Lebel Sophie, Thewes Belinda, Kwakkenbos Linda, Custers José A E
Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Medical Psychology, 6525 Nijmegen, The Netherlands.
School of Psychology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Cancers (Basel). 2022 Aug 11;14(16):3889. doi: 10.3390/cancers14163889.
(1) Background: Studies examining the psychosocial impact of living long term on systemic treatment in advanced cancer patients are scarce. This scoping review aimed to answer the research question "What has been reported about psychosocial factors among patients living with advanced cancer receiving life-long systemic treatment?", by synthesizing psychosocial data, and evaluating the terminology used to address these patients; (2) Methods: This scoping review was conducted following the five stages of the framework of Arksey and O'Malley (2005); (3) Results: 141 articles published between 2000 and 2021 (69% after 2015) were included. A large variety of terms referring to the patient group was observed. Synthesizing qualitative studies identified ongoing uncertainty, anxiety and fear of disease progression or death, hope in treatment results and new treatment options, loss in several aspects of life, and worries about the impact of disease on loved ones and changes in social life to be prominent psychosocial themes. Of 82 quantitative studies included in the review, 76% examined quality of life, 46% fear of disease progression or death, 26% distress or depression, and 4% hope, while few studies reported on adaptation or cognitive aspects. No quantitative studies focused on uncertainty, loss, or social impact; (4) Conclusion and clinical implications: Prominent psychosocial themes reported in qualitative studies were not included in quantitative research using specific validated questionnaires. More robust studies using quantitative research designs should be conducted to further understand these psychological constructs. Furthermore, the diversity of terminology found in the literature calls for a uniform definition to better address this specific patient group in research and in practice.
(1) 背景：关于晚期癌症患者长期接受全身治疗的社会心理影响的研究很少。本范围综述旨在通过综合社会心理数据并评估用于描述这些患者的术语，回答研究问题“关于接受终身全身治疗的晚期癌症患者的社会心理因素有哪些报道？”；(2) 方法：本范围综述遵循Arksey和O'Malley（2005年）框架的五个阶段进行；(3) 结果：纳入了2000年至2021年发表的141篇文章（2015年后发表的占69%）。观察到大量指代该患者群体的术语。综合定性研究发现，持续的不确定性、对疾病进展或死亡的焦虑和恐惧、对治疗结果和新治疗选择的希望、生活多个方面的丧失，以及对疾病对亲人的影响和社会生活变化的担忧是突出的社会心理主题。在纳入综述的82项定量研究中，76%研究了生活质量，46%研究了对疾病进展或死亡的恐惧，26%研究了痛苦或抑郁，4%研究了希望，而很少有研究报告适应或认知方面。没有定量研究关注不确定性、丧失或社会影响；(4) 结论及临床意义：定性研究中报告的突出社会心理主题未被使用特定有效问卷的定量研究所涵盖。应进行更有力的定量研究设计研究，以进一步了解这些心理结构。此外，文献中发现的术语多样性要求有一个统一的定义，以便在研究和实践中更好地描述这一特定患者群体。
