Hassing Linda B, Johansson Boo, Nilsson Sven E, Berg Stig, Pedersen Nancy L, Gatz Margaret, McClearn Gerald
Department of Psychology, Göteborg University, Göteborg, Sweden.
Int Psychogeriatr. 2002 Sep;14(3):239-48. doi: 10.1017/s104161020200844x.
The purpose of this study was to examine if Type 2 diabetes mellitus is a risk factor for dementia in very old age, specifically for Alzheimer's disease (AD) and vascular dementia (VaD).
We evaluated the risk of dementia in relation to Type 2 diabetes using a population-based sample of 702 individuals aged 80 years and older (mean age 83 years). A total of 187 persons received a dementia diagnosis. Thirty-one individuals had a diabetes diagnosis prior to onset of the dementia.
Cox proportional hazard analyses, adjusted for age, gender, education, smoking habits, and circulatory diseases, indicated an elevated risk to develop VaD (relative risk = 2.54, 95% confidence interval 1.354.78) in individuals with diabetes mellitus. No association was found between diabetes and AD.
Type 2 diabetes is selectively related to the different subtypes of dementia. There is no increased risk of AD but more than a twofold risk of VaD in persons with diabetes.
本研究旨在探讨2型糖尿病是否为高龄人群患痴呆症的危险因素，尤其是患阿尔茨海默病（AD）和血管性痴呆（VaD）的危险因素。
我们使用了一个基于人群的样本，其中包括702名80岁及以上（平均年龄83岁）的个体，评估了2型糖尿病与痴呆症风险之间的关系。共有187人被诊断为痴呆症。31人在痴呆症发病前被诊断患有糖尿病。
经年龄、性别、教育程度、吸烟习惯和循环系统疾病校正后的Cox比例风险分析表明，糖尿病患者患VaD的风险升高（相对风险=2.54，95%置信区间1.35-4.78）。未发现糖尿病与AD之间存在关联。
2型糖尿病与痴呆症的不同亚型存在选择性关联。糖尿病患者患AD的风险没有增加，但患VaD的风险增加了两倍多。
