老年精神科住院患者的抗胆碱能药物负担与跌倒风险：一项为期4年的病例对照研究。

Anticholinergic burden and the risk of falls among elderly psychiatric inpatients: a 4-year case-control study.

作者信息

Aizenberg Dov, Sigler Mayanit, Weizman Abraham, Barak Yoram

机构信息

Geha Mental Health Center, Petah-Tiqva, Israel.

出版信息

Int Psychogeriatr. 2002 Sep;14(3):307-10. doi: 10.1017/s1041610202008505.

DOI:10.1017/s1041610202008505

PMID:12475091

Abstract

OBJECTIVE

Falls are an everyday risk for the elderly and their etiology is multifactorial. Because there are little data focusing on falls among elderly psychiatric inpatients, we aimed to retrospectively assess the characteristics of inpatients that had sustained a fall during hospitalization.

METHODS

Over 4 years, all adverse-event reports of falls were reviewed. Inclusion criteria were age >65 years and intact cognition. The control group consisted of the previous and next admission of an elderly patient to the same ward. Anticholinergic score was calculated for each patient.

RESULTS

Of 414 admissions of elderly patients, 34 (8.2%) patients had had a fall. The control group (n = 68) did not differ in mean age, distribution of diagnoses, or use of benzodiazepines, antidepressants, or antipsychotics. Two variables were significantly associated with falls: female gender (68% vs. 39%, p < .05) and anticholinergic burden score (ABS) (mean: 3.7 vs. 2.1, p < .05).

CONCLUSIONS

Our results support reported findings of higher rates of falls among elderly women and suggest that ABS may be a risk factor for falls.

摘要

目的

跌倒对老年人来说是日常风险，其病因是多因素的。由于关注老年精神科住院患者跌倒情况的数据较少，我们旨在回顾性评估住院期间发生跌倒的患者特征。

方法

在4年多的时间里，对所有跌倒不良事件报告进行了审查。纳入标准为年龄>65岁且认知完整。对照组由同一名老年患者前后两次入住同一病房组成。计算每位患者的抗胆碱能评分。

结果

在414例老年患者入院病例中，34例（8.2%）患者发生过跌倒。对照组（n = 68）在平均年龄、诊断分布或苯二氮䓬类药物、抗抑郁药或抗精神病药物的使用方面无差异。有两个变量与跌倒显著相关：女性性别（68%对39%，p < 0.05）和抗胆碱能负担评分（ABS）（平均值：3.7对2.1，p < 0.05）。