抗胆碱能作用鲜有好处。
Anticholinergic action is rarely a good thing.
作者信息
Bishara Delia
机构信息
Maudsley Hospital, Denmark Hill, UK.
出版信息
Ther Adv Psychopharmacol. 2023 Sep 8;13:20451253231195264. doi: 10.1177/20451253231195264. eCollection 2023.
Abstract
The evidence for the risks associated with anticholinergic agents has grown considerably in the last two decades. Not only are they associated with causing peripheral side effects such as dry mouth, blurred vision and constipation, but they can also cause central effects such as cognitive impairment; and more recently, they have consistently been linked with an increased risk of dementia and death in older people. This paper reviews the evidence for the associations of anticholinergic agents and the risk of dementia and increased mortality in dementia.
摘要
在过去二十年中，与抗胆碱能药物相关风险的证据大幅增加。它们不仅会引发外周副作用，如口干、视力模糊和便秘，还会导致中枢效应，如认知障碍；最近，它们一直与老年人患痴呆症和死亡风险增加有关。本文综述了抗胆碱能药物与痴呆症风险及痴呆症死亡率增加之间关联的证据。
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