抗胆碱能作用鲜有好处。
Anticholinergic action is rarely a good thing.
作者信息
Bishara Delia
机构信息
Maudsley Hospital, Denmark Hill, UK.
出版信息
Ther Adv Psychopharmacol. 2023 Sep 8;13:20451253231195264. doi: 10.1177/20451253231195264. eCollection 2023.
Abstract
The evidence for the risks associated with anticholinergic agents has grown considerably in the last two decades. Not only are they associated with causing peripheral side effects such as dry mouth, blurred vision and constipation, but they can also cause central effects such as cognitive impairment; and more recently, they have consistently been linked with an increased risk of dementia and death in older people. This paper reviews the evidence for the associations of anticholinergic agents and the risk of dementia and increased mortality in dementia.
摘要
在过去二十年中，与抗胆碱能药物相关风险的证据大幅增加。它们不仅会引发外周副作用，如口干、视力模糊和便秘，还会导致中枢效应，如认知障碍；最近，它们一直与老年人患痴呆症和死亡风险增加有关。本文综述了抗胆碱能药物与痴呆症风险及痴呆症死亡率增加之间关联的证据。
相似文献
1
Anticholinergic action is rarely a good thing.
Ther Adv Psychopharmacol. 2023 Sep 8;13:20451253231195264. doi: 10.1177/20451253231195264. eCollection 2023.
2
[Anticholinergic scales: Use in psychiatry and update of the anticholinergic impregnation scale].
Encephale. 2022 Jun;48(3):313-324. doi: 10.1016/j.encep.2021.09.004. Epub 2021 Dec 4.
3
Managing drugs with anticholinergic activity.
Drug Ther Bull. 2023 Sep;61(9):135-139. doi: 10.1136/dtb.2022.000066.
4
Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence.
Aging Clin Exp Res. 2016 Feb;28(1):25-35. doi: 10.1007/s40520-015-0359-7. Epub 2015 May 1.
5
The anticholinergic burden: from research to practice.
Aust Prescr. 2022 Aug;45(4):118-120. doi: 10.18773/austprescr.2022.031. Epub 2022 Aug 1.
6
Anticholinergic medications in community-dwelling older veterans: prevalence of anticholinergic symptoms, symptom burden, and adverse drug events.
Am J Geriatr Pharmacother. 2006 Mar;4(1):42-51. doi: 10.1016/j.amjopharm.2006.03.008.
7
Anticholinergic effects of oral antipsychotic drugs of typicals versus atypicals over medium- and long-term: systematic review and meta-analysis.
Curr Med Chem. 2012;19(30):5214-8. doi: 10.2174/092986712803530476.
8
Benefits and limits of anticholinergic use in schizophrenia: focusing on its effect on cognitive function.
Psychiatry Clin Neurosci. 2014 Jan;68(1):37-49. doi: 10.1111/pcn.12088. Epub 2013 Sep 19.
9
Anticholinergic burden before and after hospitalization in older adults with dementia: Increase due to antipsychotic medications.
Int J Geriatr Psychiatry. 2019 Jun;34(6):868-880. doi: 10.1002/gps.5084. Epub 2019 Mar 27.
10
Association between using medications with anticholinergic properties and short-term cognitive decline among older men: A retrospective cohort study in Taiwan.
Geriatr Gerontol Int. 2017 Apr;17 Suppl 1:57-64. doi: 10.1111/ggi.13032.
引用本文的文献
1
High Anticholinergic Burden of Patients Hospitalized for Hip Fracture Reveals a Target for Deprescribing.
J Am Med Dir Assoc. 2025 May;26(5):105537. doi: 10.1016/j.jamda.2025.105537. Epub 2025 Mar 21.
2
Understanding the medication regimens associated with anticholinergic burden in older people's mental health services in the UK.
BJPsych Open. 2024 Oct 3;10(5):e167. doi: 10.1192/bjo.2024.788.
本文引用的文献
1
Polypharmacy and cumulative anticholinergic burden in older adults hospitalized with fall.
Aging Med (Milton). 2023 Apr 5;6(2):116-123. doi: 10.1002/agm2.12250. eCollection 2023 Jun.
2
Association between anticholinergic burden and dementia in UK Biobank.
Alzheimers Dement (N Y). 2022 Apr 12;8(1):e12290. doi: 10.1002/trc2.12290. eCollection 2022.
3
Receipt of Overactive Bladder Drugs and Incident Dementia: A Population-based Case-control Study.
Eur Urol Focus. 2022 Sep;8(5):1433-1440. doi: 10.1016/j.euf.2021.10.009. Epub 2021 Nov 4.
4
Centrally Acting Anticholinergic Drugs Used for Urinary Conditions Associated with Worse Outcomes in Dementia.
J Am Med Dir Assoc. 2021 Dec;22(12):2547-2552. doi: 10.1016/j.jamda.2021.08.011. Epub 2021 Aug 30.
5
An association between incontinence and antipsychotic drugs: A systematic review.
Biomed Pharmacother. 2021 Oct;142:112027. doi: 10.1016/j.biopha.2021.112027. Epub 2021 Aug 12.
6
Centrally-acting anticholinergic drugs- associations with mortality, hospitalisation and cognitive decline following dementia diagnosis in people receiving antidepressant and antipsychotic drugs.
Aging Ment Health. 2022 Sep;26(9):1747-1755. doi: 10.1080/13607863.2021.1947967. Epub 2021 Jul 26.
7
Anticholinergic drugs and risk of dementia: Time for action?
Pharmacol Res Perspect. 2021 May;9(3):e00793. doi: 10.1002/prp2.793.
8
Association between Anticholinergic Burden and Constipation: A Systematic Review.
Healthcare (Basel). 2021 May 13;9(5):581. doi: 10.3390/healthcare9050581.
9
Anticholinergic drugs and the risk of dementia: A systematic review and meta-analysis.
Neurosci Biobehav Rev. 2021 Aug;127:296-306. doi: 10.1016/j.neubiorev.2021.04.031. Epub 2021 Apr 29.
10
Increased risk of incident dementia following use of anticholinergic agents: A systematic literature review and meta-analysis.
Neurourol Urodyn. 2021 Jan;40(1):28-37. doi: 10.1002/nau.24536. Epub 2020 Oct 23.
Zotero 插件