Craig E A, Marszalek J
Department of Biomolecular Chemistry, 1300 University Avenue, University of Wisconsin, Madison, Wisconsin 53706, USA.
Cell Mol Life Sci. 2002 Oct;59(10):1658-65. doi: 10.1007/pl00012493.
Mitochondria contain a specialized system of molecular chaperones that plays a critical role in the biogenesis of Fe/S centers. This Hsp70:J-protein system shows many similarities to the system found in bacteria, but the precise role of neither chaperone system has been defined. However, evidence to date suggests an interaction with the scaffold protein on which a transient Fe/S center is assembled, and thus implies a role in either assembly of the center or its transfer to recipient proteins.
线粒体包含一个特殊的分子伴侣系统，该系统在铁硫中心的生物合成中起着关键作用。这种热休克蛋白70（Hsp70）：J蛋白系统与细菌中发现的系统有许多相似之处，但两个伴侣系统的确切作用尚未明确。然而，迄今为止的证据表明，它与组装瞬时铁硫中心的支架蛋白相互作用，因此意味着它在该中心的组装或其向受体蛋白的转移中发挥作用。
