• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

作者信息

Lecaille Fabien, Kaleta Jadwiga, Brömme Dieter

机构信息

Mount Sinai School of Medicine, Department of Human Genetics, Fifth Avenue at 100th Street, New York, New York 10029, USA.

出版信息

Chem Rev. 2002 Dec;102(12):4459-88. doi: 10.1021/cr0101656.

DOI:10.1021/cr0101656
PMID:12475197
Abstract
摘要

相似文献

1
Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.人类和寄生性木瓜蛋白酶样半胱氨酸蛋白酶:它们在生理和病理中的作用以及抑制剂设计的最新进展。
Chem Rev. 2002 Dec;102(12):4459-88. doi: 10.1021/cr0101656.
2
Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design.半胱氨酸蛋白酶抑制剂作为寄生虫病的治疗方法:抑制剂设计的进展
Mini Rev Med Chem. 2006 Sep;6(9):1025-32. doi: 10.2174/138955706778195207.
3
Cysteine proteases of parasitic organisms.寄生生物的半胱氨酸蛋白酶。
Mol Biochem Parasitol. 2002 Mar;120(1):1-21. doi: 10.1016/s0166-6851(01)00438-8.
4
Cysteine proteases of malaria parasites: targets for chemotherapy.疟原虫的半胱氨酸蛋白酶:化疗靶点
Curr Pharm Des. 2002;8(18):1659-72. doi: 10.2174/1381612023394197.
5
Inhibition of cysteine protease activity by NO-donors.一氧化氮供体对半胱氨酸蛋白酶活性的抑制作用。
Curr Protein Pept Sci. 2001 Jun;2(2):137-53. doi: 10.2174/1389203013381170.
6
Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.设计、合成及生物评价强效瑞香烷肽腈类抑制剂及基于活性的探针作为有前景的抗布氏锥虫药物。
Chemistry. 2012 May 21;18(21):6528-41. doi: 10.1002/chem.201103322. Epub 2012 Apr 4.
7
Falcipains and other cysteine proteases of malaria parasites.疟原虫的 falcipains 和其他半胱氨酸蛋白酶。
Adv Exp Med Biol. 2011;712:30-48. doi: 10.1007/978-1-4419-8414-2_3.
8
Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases.木瓜蛋白酶家族半胱氨酸蛋白酶的新型氮杂肽抑制剂及活性位点探针
Chembiochem. 2006 Jun;7(6):943-50. doi: 10.1002/cbic.200600001.
9
Binding modes of a new epoxysuccinyl-peptide inhibitor of cysteine proteases. Where and how do cysteine proteases express their selectivity?一种新型半胱氨酸蛋白酶环氧琥珀酰肽抑制剂的结合模式。半胱氨酸蛋白酶在何处以及如何表现出其选择性?
Biochim Biophys Acta. 1999 May 18;1431(2):290-305. doi: 10.1016/s0167-4838(99)00053-9.
10
Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases.腺病毒蛋白酶新抑制剂先导物的发现:迈向半胱氨酸蛋白酶选择性不可逆抑制剂的步骤
FEBS Lett. 2001 Aug 3;502(3):93-7. doi: 10.1016/s0014-5793(01)02672-2.

引用本文的文献

1
A Predictive Model for Thiol Reactivity of -Heteroaryl α-Methylene-γ-Lactams─A Medicinally Relevant Covalent Reactive Group.一种用于预测 - 杂芳基α-亚甲基-γ-内酰胺硫醇反应性的模型——一种与药物相关的共价反应基团。
J Med Chem. 2025 Jun 12;68(11):11948-11961. doi: 10.1021/acs.jmedchem.5c00833. Epub 2025 May 23.
2
Construction, expression, and characterization of scFv fragment against Fasciola gigantica cathepsin L1H.针对巨片形吸虫组织蛋白酶L1H的单链抗体片段的构建、表达及特性分析
Parasitol Res. 2025 May 9;124(5):51. doi: 10.1007/s00436-025-08499-9.
3
In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication.
已批准抗生素头孢洛林酯及其代谢产物作为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)复制抑制剂的计算机模拟和体外研究
Viruses. 2025 Mar 28;17(4):491. doi: 10.3390/v17040491.
4
Identification of Potential Roles of Cathepsin B-like in the Response to Alkali Treatment in .组织中组织蛋白酶B样蛋白在碱处理反应中潜在作用的鉴定
Int J Mol Sci. 2025 Apr 3;26(7):3361. doi: 10.3390/ijms26073361.
5
Insights into Octopus maya cathepsins from metatranscriptome and genome: structure evolutionary relationships and functional role prediction in digestive processes.基于宏转录组和基因组对玛雅章鱼组织蛋白酶的见解:结构进化关系及消化过程中的功能作用预测
Biol Open. 2025 Apr 15;14(4). doi: 10.1242/bio.061778.
6
Revealing the Immune Response of Gyllenhal to Entomopathogenic Fungi Infection Through Integrative Analyses of Transcriptomics and Metabolomics.通过转录组学和代谢组学的综合分析揭示吉伦哈尔对昆虫病原真菌感染的免疫反应
Insects. 2024 Nov 28;15(12):940. doi: 10.3390/insects15120940.
7
Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment.用于治疗利什曼病的半胱氨酸蛋白酶B抑制剂的研究进展。
Curr Drug Targets. 2025;26(2):88-108. doi: 10.2174/0113894501324437240919064715.
8
Cathepsin C in health and disease: from structural insights to therapeutic prospects.组织蛋白酶 C 在健康和疾病中的作用:从结构见解到治疗前景。
J Transl Med. 2024 Aug 20;22(1):777. doi: 10.1186/s12967-024-05589-7.
9
Broadening Horizons: Exploring the Cathepsin Family as Therapeutic Targets for Alzheimer's Disease.拓展视野:探索组织蛋白酶家族作为阿尔茨海默病的治疗靶点
Aging Dis. 2024 Jul 27. doi: 10.14336/AD.2024.0456.
10
Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L.二肽基酮迈克尔受体弹头对半胱氨酸蛋白酶组织蛋白酶L抑制机制的影响
ACS Catal. 2023 Oct 3;13(20):13354-13368. doi: 10.1021/acscatal.3c02748. eCollection 2023 Oct 20.