Lang Meidong, Grzesiak Adam L, Matzger Adam J
Department of Chemistry and the Macromolecular Science and Engineering Program, The University of Michigan, Ann Arbor, MI 48109-1055, USA.
J Am Chem Soc. 2002 Dec 18;124(50):14834-5. doi: 10.1021/ja0286526.
A method for the production of crystalline polymorphs from solution is described which utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This method provides a new paradigm for polymorph selection, where solvent and temperature conditions can be chosen on the basis of process considerations and the polymer heteronucleus can be varied for specific polymorph production.
描述了一种从溶液中制备结晶多晶型物的方法，该方法利用了多种聚合物异质核。展示了其在重要药物对乙酰氨基酚和卡马西平的结晶多晶型物选择中的应用。该方法为多晶型物选择提供了一种新范式，其中可以根据工艺考虑选择溶剂和温度条件，并且可以针对特定多晶型物的生产改变聚合物异质核。
