[加巴喷丁与聚合物异核体的晶型控制与选择]
[The crystalline polymorph control and selection of gabapentin with polymer heteronuclei].
作者信息
Yang Liu, Ru Min-Liang, Lang Mei-Dong
机构信息
Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
出版信息
Yao Xue Xue Bao. 2010 Jan;45(1):109-13.
The pharmaceutical properties, including the physical and chemical properties, and the bioavailability are greatly influenced by their polymorphism. In this paper the polymer heteronuclei were used to produce the gabapentin polymorphs that were characterized by X-ray powder diffraction, FT-IR and DSC. The results indicated that the polymer heteronuclei are an effective method to control and select the gabapentin polymorphism. One new polymorph of gabapentin was found besides all known gabapentin polymorphs.
药物性质，包括物理和化学性质，以及生物利用度，都受到其多晶型的极大影响。本文采用聚合物异核体来制备加巴喷丁多晶型物，并通过X射线粉末衍射、傅里叶变换红外光谱和差示扫描量热法对其进行表征。结果表明，聚合物异核体是控制和选择加巴喷丁多晶型的有效方法。除了所有已知的加巴喷丁多晶型物外，还发现了一种新的加巴喷丁多晶型物。
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