Cbl-ArgBP2复合物介导c-Abl的泛素化和降解。
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
作者信息
Soubeyran Philippe, Barac Ana, Szymkiewicz Iwona, Dikic Ivan
机构信息
Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S-75124, Sweden.
出版信息
Biochem J. 2003 Feb 15;370(Pt 1):29-34. doi: 10.1042/BJ20021539.
Abstract
The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.
摘要
导致活化的c-Abl激酶泛素化和降解的机制尚未明确。我们发现多接头蛋白ArgBP2将c-Abl与泛素连接酶Cbl相连。c-Abl对Cbl和ArgBP2的磷酸化导致它们相互作用的稳定，从而促进Cbl诱导的c-Abl和ArgBP2的泛素化及随后的降解。
相似文献
1
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.Cbl-ArgBP2复合物介导c-Abl的泛素化和降解。
Biochem J. 2003 Feb 15;370(Pt 1):29-34. doi: 10.1042/BJ20021539.
2
3
Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.过氧化氢酶受泛素化和蛋白酶体降解的调控。c-Abl和Arg酪氨酸激酶的作用。
Biochemistry. 2003 Sep 9;42(35):10348-53. doi: 10.1021/bi035023f.
4
Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases.鉴定磷脂酰肌醇-3激酶（PI3激酶）的B细胞衔接蛋白（BCAP）为Abl相互作用分子1调节的Abl激酶底物。
FEBS Lett. 2005 Jun 6;579(14):2986-90. doi: 10.1016/j.febslet.2005.04.052.
5
Abl family kinases and Cbl cooperate with the Nck adaptor to modulate Xenopus development.Abl家族激酶和Cbl与Nck衔接蛋白协同作用，调节非洲爪蟾的发育。
J Biol Chem. 2000 Nov 17;275(46):36472-8. doi: 10.1074/jbc.M005424200.
6
CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration.CIP4 是一个新的 ArgBP2 相互作用蛋白，可调节 ArgBP2 介导的 WAVE1 磷酸化和癌细胞迁移的控制。
Cancer Lett. 2010 Feb 1;288(1):116-23. doi: 10.1016/j.canlet.2009.06.030. Epub 2009 Jul 23.
7
Homo- and hetero-oligomerization of the c-Abl kinase and Abelson-interactor-1.c-Abl激酶与Abelson相互作用蛋白-1的同源和异源寡聚化
Cancer Res. 2003 Feb 15;63(4):873-7.
8
SH3P2 in complex with Cbl and Src.与Cbl和Src形成复合物的SH3P2。
FEBS Lett. 2004 May 7;565(1-3):33-8. doi: 10.1016/j.febslet.2004.03.100.
9
Ubiquitin-dependent degradation of Id1 and Id3 is mediated by the COP9 signalosome.Id1和Id3的泛素依赖性降解由COP9信号体介导。
J Mol Biol. 2004 Oct 15;343(2):361-70. doi: 10.1016/j.jmb.2004.08.043.
10
Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.活化的abl诱导肿瘤涉及cbl癌基因产物的酪氨酸磷酸化。
EMBO J. 1994 Oct 3;13(19):4515-23. doi: 10.1002/j.1460-2075.1994.tb06773.x.
引用本文的文献
1
The Ubiquitin-Proteasome System in Apoptosis and Apoptotic Cell Clearance.凋亡及凋亡细胞清除中的泛素-蛋白酶体系统
Front Cell Dev Biol. 2022 Jul 6;10:914288. doi: 10.3389/fcell.2022.914288. eCollection 2022.
2
Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.心肌细胞中 Sorbin 和 SH3 域包含 2 型（Sorbs2）的敲除导致小鼠扩张型心肌病。
J Am Heart Assoc. 2022 Jul 5;11(13):e025687. doi: 10.1161/JAHA.122.025687. Epub 2022 Jun 22.
3
Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance.抗凋亡蛋白 HAX-1 通过促进 c-Abl 激酶相关的 ROS 清除来抑制细胞凋亡。
Cell Death Dis. 2022 Apr 4;13(4):298. doi: 10.1038/s41419-022-04748-2.
4
is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.是导致 4q 缺失综合征患者心脏畸形的遗传因素。
Elife. 2021 Jun 8;10:e67481. doi: 10.7554/eLife.67481.
5
Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.艾伯尔森激酶的无规则结构区域在蛋白质功能和蛋白质稳定性方面发挥着重要作用。
Cell Commun Signal. 2021 Feb 24;19(1):27. doi: 10.1186/s12964-020-00703-w.
6
RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.RNA 结合蛋白 SORBS2 通过增强 MTUS1 mRNA 的稳定性来抑制肾透明细胞癌转移。
Cell Death Dis. 2020 Dec 12;11(12):1056. doi: 10.1038/s41419-020-03268-1.
7
Ponatinib and other CML Tyrosine Kinase Inhibitors in Thrombosis.波那替尼和其他 CML 酪氨酸激酶抑制剂在血栓形成中的作用。
Int J Mol Sci. 2020 Sep 8;21(18):6556. doi: 10.3390/ijms21186556.
8
SORBS2, mediated by MEF2D, suppresses the metastasis of human hepatocellular carcinoma by inhibitiing the c-Abl-ERK signaling pathway.由MEF2D介导的SORBS2通过抑制c-Abl-ERK信号通路抑制人肝细胞癌的转移。
Am J Cancer Res. 2019 Dec 1;9(12):2706-2718. eCollection 2019.
9
Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion.去磷酸化酶 PP2A-Bδ 对 HDAC4 的去磷酸化作用揭示了 HDAC4/MEF2 轴在成肌细胞融合中的新作用。
Cell Death Dis. 2019 Jul 4;10(7):512. doi: 10.1038/s41419-019-1743-6.
10
Proteome profiling of triple negative breast cancer cells overexpressing NOD1 and NOD2 receptors unveils molecular signatures of malignant cell proliferation.NOD1 和 NOD2 受体过表达的三阴性乳腺癌细胞的蛋白质组谱分析揭示了恶性细胞增殖的分子特征。
BMC Genomics. 2019 Feb 21;20(1):152. doi: 10.1186/s12864-019-5523-6.
本文引用的文献
1
CIN85/CMS family of adaptor molecules.衔接分子CIN85/CMS家族
FEBS Lett. 2002 Oct 2;529(1):110-5. doi: 10.1016/s0014-5793(02)03188-5.
2
Negative regulation of Lck by Cbl ubiquitin ligase.Cbl泛素连接酶对Lck的负调控。
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3794-9. doi: 10.1073/pnas.062055999.
3
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.内吞蛋白-CIN85-Cbl复合物介导c-Met的配体依赖性下调。
Nature. 2002 Mar 14;416(6877):187-90. doi: 10.1038/416187a.
4
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.Cbl-CIN85-内吞蛋白复合物介导配体诱导的表皮生长因子受体下调。
Nature. 2002 Mar 14;416(6877):183-7. doi: 10.1038/416183a.
5
Autoinhibition of c-Abl.c-Abl的自抑制
Cell. 2002 Jan 25;108(2):247-59. doi: 10.1016/s0092-8674(02)00623-2.
6
The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.非受体酪氨酸激酶Syk是B细胞受体刺激后Cbl介导的泛素化作用的靶点。
EMBO J. 2001 Dec 17;20(24):7085-95. doi: 10.1093/emboj/20.24.7085.
7
Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway.
Curr Biol. 2001 Nov 13;11(22):1759-65. doi: 10.1016/s0960-9822(01)00538-3.
8
Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor.Abl酪氨酸激酶和Nck SH2/SH3衔接蛋白对Cbl磷酸化的调控。
Oncogene. 2001 Jul 5;20(30):4058-69. doi: 10.1038/sj.onc.1204528.
9
The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.索宾同源结构域：一种将蛋白质靶向脂筏的基序。
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9098-103. doi: 10.1073/pnas.151252898.
10
Cbl: many adaptations to regulate protein tyrosine kinases.Cbl：多种用于调节蛋白酪氨酸激酶的适应性变化。
Nat Rev Mol Cell Biol. 2001 Apr;2(4):294-307. doi: 10.1038/35067100.
Zotero 插件