[肿瘤坏死因子A - 308基因多态性与成人重度牙周炎易感性的关系]
[The relationship between tumor necrosis factor A-308 gene polymorphism and susceptibility of severe periodontitis in adults].
作者信息
Qian Wei, Zhang Jincai, Zhang Yunhui
机构信息
Department of Periodontics, Beijing Stomatology Hospital, Capital University of Medical Sciences, Beijing 100050, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2002 Mar;37(2):126-8.
OBJECTIVE
To investigate the relationship between tumor necrosis factor A-308 gene polymorphism and susceptibility of severe periodontitis in adults.
METHODS
Buccal swabs from 65 adult patients with severe periodontitis and 96 periodontal healthy adult controls were obtained. DNA was extracted from each sample using Chelex-100 method, then PCR-RFLP was performed to determine the TNFA-308 genotype. Data were analyzed by statistics software.
RESULTS
A significant difference of genotype distribution was found between the patients and controls. The percentage of 1/1 type of the patients was much higher (P < 0.001). Risk Analysis showed odds ratio for allele 1 was 4.64.
CONCLUSION
This study suggested that TNFA-308 allele 1 maybe a marker of susceptibility to severe periodontitis.
目的
探讨肿瘤坏死因子A - 308基因多态性与成人重度牙周炎易感性之间的关系。
方法
采集65例成人重度牙周炎患者和96例牙周健康成人对照的颊拭子。采用Chelex - 100法从每个样本中提取DNA，然后进行聚合酶链反应 - 限制性片段长度多态性分析（PCR - RFLP）以确定TNFA - 308基因型。使用统计软件对数据进行分析。
结果
患者与对照之间基因型分布存在显著差异。患者中1/1型的百分比更高（P < 0.001）。风险分析显示等位基因1的优势比为4.64。
结论
本研究提示TNFA - 308等位基因1可能是重度牙周炎易感性的一个标志物。
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