Zhao Ke, Cheng Xiangrong, Li Zhian, Yi Anhua, Ma Li
Presently working as postdoctoral fellow in West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2002 Mar;37(2):150-2.
To prepare a new synthetic macromolecular resin class of denture adhesive (named Comfort-DA).
Twelve different formulae for denture adhesive were designed by orthogonal design. Each factor affecting tensile bond strength of adhesive was analyzed by ANNOVA to select the best formula. Then the chemical and physical properties, such as tensile bond strength, pH value, and viscosity, were evaluated and compared with Fittydent in vitro also.
The effect of content of polyvinyl acetate and cellulose ether on tensile bond strength exhibited no statistical significance (P > 0.05), while ethyl alcohol and CMC-Na showed statistical significance and mutual action (P < 0.05). Results of testing viscosity and shearing stress showed that there was no significant difference between Fittydent and Comfort-DA (P > 0.05), while Fittydent exhibited a significantly lower tensile bond strength than the prepared one (P < 0.05). The prepared adhesive demonstrated a neutral or slightly basic pH.
The generally favorable in vitro performance of the prepared adhesive (Comfort-DA) formulation indicated that it might be efficacious denture adhesive.
制备一种新型合成高分子树脂类义齿黏附剂（命名为Comfort-DA）。
采用正交设计法设计12种不同配方的义齿黏附剂。通过方差分析对影响黏附剂拉伸粘结强度的各因素进行分析，以筛选出最佳配方。然后对其化学和物理性能，如拉伸粘结强度、pH值和黏度进行评估，并在体外与Fittydent进行比较。
聚醋酸乙烯酯和纤维素醚含量对拉伸粘结强度的影响无统计学意义（P>0.05），而乙醇和羧甲基纤维素钠具有统计学意义且存在交互作用（P<0.05）。黏度和剪切应力测试结果表明，Fittydent与Comfort-DA之间无显著差异（P>0.05），但Fittydent的拉伸粘结强度显著低于制备的黏附剂（P<0.05）。制备的黏附剂呈中性或弱碱性pH。
制备的黏附剂（Comfort-DA）配方在体外的总体性能良好，表明它可能是一种有效的义齿黏附剂。
