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The economic consequences of preterm birth during the first 10 years of life.生命最初10年中早产的经济后果。
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4
The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor.用于治疗早产的随机一氧化氮抑制宫缩试验（RNOTT）
Am J Obstet Gynecol. 2004 Sep;191(3):683-90. doi: 10.1016/j.ajog.2004.02.019.
5
Nitric oxide metabolites in preterm and induced labor.
Gynecol Obstet Invest. 2003;56(4):197-202. doi: 10.1159/000074452. Epub 2003 Oct 23.
6
ACOG practice bulletin. Management of preterm labor. Number 43, May 2003.美国妇产科医师学会实践公告。早产的管理。第43号，2003年5月。
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7
What are the realistic expectations of tocolytics?
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Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate.
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9
Preterm delivery.早产
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硝酸甘油用于治疗早产。

Glyceryl trinitrate for the treatment of preterm labor.

作者信息

Çalışkan Şafak, Narin Mehmet Ali, Dede Faruk Suat, Narin Raziye, Dede Hülya, Kandemir Ömer

机构信息

Clinic of Obstetrics and Gynecology, Nazilli State Hospital, Aydın, Turkey.

Department of Obstetrics and Gynecology, Erzincan University Faculty of Medicine, Erzincan, Turkey.

出版信息

J Turk Ger Gynecol Assoc. 2015 Jul 14;16(3):174-8. doi: 10.5152/jtgga.2015.15016. eCollection 2015.

DOI:10.5152/jtgga.2015.15016
PMID:26401112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4560476/
Abstract

OBJECTIVE

This study was conducted to compare the tocolytic efficacy of glyceryltrinitrate (GTN) with that of magnesium sulfate (MgSO4) and to investigate serum nitric oxide metabolites before and after tocolysis.

MATERIAL AND METHODS

In total, 48 women between 27 and 34 weeks' gestation with threatened preterm labor and intact membranes were randomly allocated to receive either GTN or MgSO4 tocolysis. Main outcome measures included tocolytic efficacy and maternal side effect(s) of the tocolytic agent. Obstetric and neonatal outcomes as well as pretreatment and posttreatment nitric oxide (NO) metabolites were assessed.

RESULTS

Forty-one patients were included into the final analysis. Uterine contraction cessation times were 3.66±1.28 and 6.83±3.47 hours for GTN and MgSO4 groups, respectively. Similarly, maternal side effects were significantly lower in the GTN group than in the MgSO4 group, and no serious maternal side effects were recorded. Serum NO metabolite levels before treatment were significantly lower in the treatment groups than in the controls. Serum nitrite levels were significantly increased after tocolytic treatment both in MgSO4 and GTN groups.

CONCLUSION

GTN effectively delays preterm delivery and reduces neonatal morbidity and mortality with less maternal side effects and seems to be an effective and safe alternative to MgSO4.

摘要

目的

本研究旨在比较硝酸甘油（GTN）与硫酸镁（MgSO4）的保胎疗效，并研究保胎前后血清一氧化氮代谢产物。

材料与方法

总共48例妊娠27至34周、有先兆早产且胎膜完整的女性被随机分配接受GTN或MgSO4保胎治疗。主要观察指标包括保胎药物的保胎疗效和母体副作用。评估产科和新生儿结局以及治疗前和治疗后一氧化氮（NO）代谢产物。

结果

41例患者纳入最终分析。GTN组和MgSO4组的子宫收缩停止时间分别为3.66±1.28小时和6.83±3.47小时。同样，GTN组的母体副作用明显低于MgSO4组，且未记录到严重的母体副作用。治疗组治疗前血清NO代谢产物水平明显低于对照组。MgSO4组和GTN组在保胎治疗后血清亚硝酸盐水平均显著升高。

结论

GTN能有效延迟早产，降低新生儿发病率和死亡率，且母体副作用较少，似乎是MgSO4的一种有效且安全的替代药物。