Laban Christiana, Bustin Stephen A, Jenkins Paul J
Department of Breast Surgery, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
Trends Endocrinol Metab. 2003 Jan;14(1):28-34. doi: 10.1016/s1043-2760(02)00003-6.
The growth hormone-insulin-like growth factor-I (GH-IGF-I) axis plays a fundamental role in the development of the breast. The maintenance of breast tissue architecture is aided by its effect on proliferation, differentiation and apoptosis. There has been increasing recognition of its role as a major determinant of breast cancer and, more recently, its involvement in the development of resistance to both tamoxifen and an important novel therapy for advanced disease, trastuzumab (Herceptin). Here, we discuss the influence of the GH-IGF-I axis in normal mammary development and homeostasis, its putative role in breast tumorigenesis and its interactions with estrogen signalling.
生长激素-胰岛素样生长因子-I（GH-IGF-I）轴在乳腺发育中起重要作用。它对细胞增殖、分化和凋亡的影响有助于维持乳腺组织结构。人们越来越认识到它作为乳腺癌主要决定因素的作用，最近还认识到它参与了对他莫昔芬以及一种针对晚期疾病的重要新疗法曲妥珠单抗（赫赛汀）的耐药性发展。在此，我们讨论GH-IGF-I轴在正常乳腺发育和内环境稳定中的影响、其在乳腺肿瘤发生中的假定作用以及它与雌激素信号传导的相互作用。
