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全身照射、自体骨髓移植及合成代谢类固醇治疗后的髓系再生。

Myeloid regeneration after whole body irradiation, autologous bone marrow transplantation, and treatment with an anabolic steroid.

作者信息

Ambrus C M, Ambrus J L

出版信息

J Med. 1975;6(1):27-32.

PMID:124758
Abstract

Stumptail monkeys (Macaca speciosa) received lethal whole body radiation. Autologous bone marrow injection resulted in survival of the majority of the animals. Treatment with Deca-Durabolin, an anabolic steroid, caused more rapid recovery of colony-forming cell numbers in the bone marrow than in control animals. Both the Deca-Durabolin-treated and control groups were given autologous bone marrow transplantation. Anabolic steroid effect on transplanted bone marrow colonyforming cells may explain the increased rate of leukopoietic regeneration in anabolic steroid-treated animals as compared to controls.

摘要

短尾猴(食蟹猴)接受了致死剂量的全身辐射。自体骨髓注射使大多数动物存活下来。使用合成代谢类固醇癸酸诺龙进行治疗,导致骨髓中集落形成细胞数量的恢复比对照动物更快。癸酸诺龙治疗组和对照组都接受了自体骨髓移植。合成代谢类固醇对移植骨髓集落形成细胞的作用,可能解释了与对照组相比,接受合成代谢类固醇治疗的动物中白细胞生成再生率增加的原因。

相似文献

1
Myeloid regeneration after whole body irradiation, autologous bone marrow transplantation, and treatment with an anabolic steroid.全身照射、自体骨髓移植及合成代谢类固醇治疗后的髓系再生。
J Med. 1975;6(1):27-32.
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Erythroid and myeloid regeneration after nitrogen mustard therapy, autologous bone marrow transplantation, and treatment with an anabolic steroid.氮芥疗法、自体骨髓移植及合成代谢类固醇治疗后的红系和髓系再生
J Med. 1976;7(1):47-62.
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Effect of autologous bone marrow transplantation and an anabolic steroid on erythropoietin production and hemopoietic recovery after whole body irradiation and treatment with alkylating agents.自体骨髓移植和合成代谢类固醇对全身照射及烷化剂治疗后促红细胞生成素产生和造血恢复的影响。
J Med. 1973;4(2):65-81.
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Lack of efficacy of thrombopoietin and granulocyte colony-stimulating factor after high dose total-body irradiation and autologous stem cell or bone marrow transplantation in rhesus monkeys.在恒河猴中,高剂量全身照射及自体干细胞或骨髓移植后血小板生成素和粒细胞集落刺激因子的疗效欠佳。
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Antileukemic effect of interleukin-2-transduced murine bone marrow after autologous transplantation.自体移植后白细胞介素-2转导的小鼠骨髓的抗白血病作用
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Simultaneous administration of TPO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells.对恒河猴进行细胞减灭治疗后同时给予血小板生成素(TPO)和粒细胞集落刺激因子(G-CSF)可预防血小板减少,加速血小板和红细胞重建,减轻中性粒细胞减少,并促进未成熟骨髓细胞的恢复。
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Changes in hemopoiesis of dying and surviving mice after fractionated irradiation and repeated bone marrow transplantation.
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Proliferative response of human marrow myeloid progenitor cells to in vivo treatment with granulocyte colony-stimulating factor alone and in combination with interleukin-3 after autologous bone marrow transplantation.自体骨髓移植后,人骨髓髓系祖细胞对单独使用粒细胞集落刺激因子以及联合白细胞介素-3进行体内治疗的增殖反应。
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[Granulocyte colony-stimulating factor-mobilized autologous bone marrow stem cells promote the liver regeneration of partial liver transplant: an experiment with rats].[粒细胞集落刺激因子动员的自体骨髓干细胞促进部分肝移植大鼠的肝脏再生:一项实验研究]
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3-Tesla MR spectroscopy in patients subjected to bone marrow transplantation: clinical correlations.3T 磁共振波谱在骨髓移植患者中的应用:临床相关性。
Radiol Med. 2013 Feb;118(1):101-11. doi: 10.1007/s11547-012-0796-8. Epub 2012 Feb 10.
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Characterization of bone marrow after transplantation by means of magnetic resonance.通过磁共振对移植后的骨髓进行表征。
Ann Hematol. 1995 Jan;70(1):3-13. doi: 10.1007/BF01715375.