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氮芥疗法、自体骨髓移植及合成代谢类固醇治疗后的红系和髓系再生

Erythroid and myeloid regeneration after nitrogen mustard therapy, autologous bone marrow transplantation, and treatment with an anabolic steroid.

作者信息

Ambrus J L, Ambrus C M, Mirand E A

出版信息

J Med. 1976;7(1):47-62.

PMID:819607
Abstract

Stumptailed monkeys (Macaca arctoides) received a lethal nitrogen mustard injection. Autologous bone marrow reinjection resulted in survival of the majority of animals. Treatment with an anabolic steroid accelerated erythropoietic and leukopoietic recovery. This appears to be related to increased erythropoietin production and increased number of colony forming units in the bone marrow.

摘要

断尾猴(熊猴)接受了致死剂量的氮芥注射。自体骨髓再注射使大多数动物存活下来。用一种合成代谢类固醇进行治疗加速了红细胞生成和白细胞生成的恢复。这似乎与促红细胞生成素产量增加以及骨髓中集落形成单位数量增加有关。

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