Vignaux Olivier, Dhote Robin, Duboc Denis, Blanche Philippe, Dusser Daniel, Weber Simon, Legmann Paul
Departments of Radiology, Université René Descartes, Hôpital Cochin, 27 rue du Fg Saint Jacques, 75679 Paris Cedex 14, France.
Chest. 2002 Dec;122(6):1895-901. doi: 10.1378/chest.122.6.1895.
To assess the follow-up of patients with sarcoidosis and myocardial MRI abnormalities.
Twelve patients with histologically proven sarcoidosis and highly suspected cardiac involvement underwent initial and 12-month follow-up cardiac assessment including cardiac MRI (T2-weighted, functional gradient echo, and T1-weighted gadolinium-diethylenetriamine penta-acetic acid-enhanced sequences). MRI abnormalities and clinical and MRI progression were scored by two observers.
Six patients receiving corticosteroid therapy (including three patients with clinical cardiac involvement) were scored as having cleared or improved at MRI follow-up, while others were seen to have worsened or remained stable. The stability, improvement, or clearing of MRI findings were correlated with clinically stable, improved or cleared sarcoidosis, while a worsening at MRI follow-up was correlated with a worsening of sarcoidosis and, in one patient, was predictive of clinical cardiac involvement.
Cardiac MRI is a useful noninvasive method for the early diagnosis and follow-up of cardiac sarcoidosis.
评估结节病合并心肌磁共振成像（MRI）异常患者的随访情况。
12例经组织学证实为结节病且高度怀疑有心脏受累的患者接受了初始及12个月的随访心脏评估，包括心脏MRI（T2加权、功能梯度回波和T1加权钆喷酸葡胺增强序列）。两名观察者对MRI异常以及临床和MRI进展进行评分。
6例接受皮质类固醇治疗的患者（包括3例有临床心脏受累的患者）在MRI随访时被评为病变清除或改善，而其他患者则被发现病情恶化或保持稳定。MRI表现的稳定、改善或清除与临床结节病稳定、改善或清除相关，而MRI随访时病情恶化与结节病恶化相关，且在1例患者中，还可预测临床心脏受累情况。
心脏MRI是心脏结节病早期诊断和随访的一种有用的非侵入性方法。
