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Identification of an organelle receptor for myosin-Va.肌球蛋白-Va细胞器受体的鉴定
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Motor-cargo interactions: the key to transport specificity.运动与货物的相互作用：运输特异性的关键。
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Regulation of Golgi structure and function by ARF-like protein 1 (Arl1).ARF样蛋白1（Arl1）对高尔基体结构和功能的调控
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Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER.鉴定rabaptin-5、rabex-5和GM130为rab33b的假定效应器，rab33b是一种参与高尔基体与内质网之间逆行运输的调节因子。
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8
The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors.Rab7效应蛋白RILP通过诱导动力蛋白-动力蛋白激活蛋白复合物的募集来控制溶酶体运输。
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高尔基体通过Rab34与Rab相互作用溶酶体蛋白的相互作用对溶酶体定位进行细胞器间调控。

Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein.

作者信息

Wang Tuanlao, Hong Wanjin

机构信息

Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Singapore.

出版信息

Mol Biol Cell. 2002 Dec;13(12):4317-32. doi: 10.1091/mbc.e02-05-0280.

DOI:10.1091/mbc.e02-05-0280
PMID:12475955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC138636/
Abstract

We present evidence to suggest the existence of a regulatory pathway for the Golgi apparatus to modulate the spatial positioning of otherwise distantly located lysosomes. Rab34, a new member of the Rab GTPase family, is associated primarily with the Golgi apparatus. Expression of wild-type or GTP-restricted but not GDP-restricted versions of Rab34 causes spatial redistribution of lysosomes from the periphery to the peri-Golgi region. The regulation of lysosomal positioning by Rab34 depends on its association with the membrane mediated by prenylation and its direct interaction with Rab-interacting lysosomal protein (RILP). This biological activity, mediated by Rab34-RILP interaction, is dependent on Lys82 in the switch I region. Our results have uncovered a novel mechanism for the Golgi apparatus to regulate the spatial distribution of another organelle.

摘要

我们提供的证据表明存在一种调节途径，通过该途径高尔基体可调节原本位于远处的溶酶体的空间定位。Rab34是Rab GTPase家族的新成员，主要与高尔基体相关。野生型或GTP受限型（而非GDP受限型）Rab34的表达会导致溶酶体从细胞周边向高尔基体周围区域发生空间重新分布。Rab34对溶酶体定位的调节取决于其通过异戊二烯化介导的与膜的结合以及与Rab相互作用溶酶体蛋白（RILP）的直接相互作用。这种由Rab34-RILP相互作用介导的生物学活性依赖于开关I区域中的赖氨酸82。我们的研究结果揭示了高尔基体调节另一种细胞器空间分布的新机制。