Havlioglu Necat, Yuan Liya, Tang Hao, Wu Jane Y
Departments of Pediatrics and Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri, USA.
J Neurovirol. 2002 Dec;8(6):486-95. doi: 10.1080/13550280290100987.
Recent studies suggest that molecules important for guiding neuronal migration and axon path-finding also play a role in modulating leukocyte chemotaxis. Neuronal migration and leukocyte chemotaxis may share some common regulatory mechanisms. Intracellular signal transduction mechanisms guiding neuronal migration and leukocyte chemotaxis are beginning to be elucidated. Studying molecular mechanisms modulating cell migration may provide new insights into understanding of endogenous inhibitors of inflammation.
最近的研究表明，对引导神经元迁移和轴突寻路很重要的分子在调节白细胞趋化性中也发挥作用。神经元迁移和白细胞趋化性可能共享一些共同的调节机制。引导神经元迁移和白细胞趋化性的细胞内信号转导机制正开始被阐明。研究调节细胞迁移的分子机制可能为理解内源性炎症抑制剂提供新的见解。
