Slit蛋白，炎症的潜在内源性调节因子。
Slit proteins, potential endogenous modulators of inflammation.
作者信息
Havlioglu Necat, Yuan Liya, Tang Hao, Wu Jane Y
机构信息
Departments of Pediatrics and Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri, USA.
出版信息
J Neurovirol. 2002 Dec;8(6):486-95. doi: 10.1080/13550280290100987.
Abstract
Recent studies suggest that molecules important for guiding neuronal migration and axon path-finding also play a role in modulating leukocyte chemotaxis. Neuronal migration and leukocyte chemotaxis may share some common regulatory mechanisms. Intracellular signal transduction mechanisms guiding neuronal migration and leukocyte chemotaxis are beginning to be elucidated. Studying molecular mechanisms modulating cell migration may provide new insights into understanding of endogenous inhibitors of inflammation.
摘要
最近的研究表明，对引导神经元迁移和轴突寻路很重要的分子在调节白细胞趋化性中也发挥作用。神经元迁移和白细胞趋化性可能共享一些共同的调节机制。引导神经元迁移和白细胞趋化性的细胞内信号转导机制正开始被阐明。研究调节细胞迁移的分子机制可能为理解内源性炎症抑制剂提供新的见解。
相似文献
1
Slit proteins, potential endogenous modulators of inflammation.Slit蛋白，炎症的潜在内源性调节因子。
J Neurovirol. 2002 Dec;8(6):486-95. doi: 10.1080/13550280290100987.
2
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors.神经元排斥分子Slit可抑制趋化因子诱导的白细胞趋化作用。
Nature. 2001 Apr 19;410(6831):948-52. doi: 10.1038/35073616.
3
Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.Slit蛋白：从神经元到白细胞等各类细胞的分子引导信号。
Curr Opin Genet Dev. 2002 Oct;12(5):583-91. doi: 10.1016/s0959-437x(02)00343-x.
4
Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation. repulsive guidance molecule-A (RGM-A) 抑制白细胞迁移并减轻炎症。
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6555-60. doi: 10.1073/pnas.1015605108. Epub 2011 Apr 5.
5
Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis.缝隙蛋白在实验性新月体性肾小球肾炎体内对炎症的调节作用。
Am J Pathol. 2004 Jul;165(1):341-52. doi: 10.1016/S0002-9440(10)63301-9.
6
Directional guidance of neuronal migration in the olfactory system by the protein Slit.蛋白质Slit对嗅觉系统中神经元迁移的定向引导
Nature. 1999 Jul 22;400(6742):331-6. doi: 10.1038/22477.
7
Probing structural homologies in cell-specific glycoproteins in the leech CNS.
Brain Res. 1986 Jul 16;378(1):152-7. doi: 10.1016/0006-8993(86)90297-0.
8
Slit: a roadblock for chemotaxis.
Sci STKE. 2001 Jul 17;2001(91):pe1. doi: 10.1126/stke.2001.91.pe1.
9
The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons.Slit蛋白中的N端富含亮氨酸区域足以排斥嗅球轴突和脑室下区神经元。
J Neurosci. 2001 Mar 1;21(5):1548-56. doi: 10.1523/JNEUROSCI.21-05-01548.2001.
10
The LHRH-astroglial network of signals as a model to study neuroimmune interactions: assessment of messenger systems and transduction mechanisms at cellular and molecular levels.作为研究神经免疫相互作用模型的促黄体生成素释放激素-星形胶质细胞信号网络：细胞和分子水平上信使系统与转导机制的评估
Neuroimmunomodulation. 1996 Jan-Feb;3(1):1-27. doi: 10.1159/000097223.
引用本文的文献
1
Concomitant induction of SLIT3 and microRNA-218-2 in macrophages by toll-like receptor 4 activation limits osteoclast commitment.Toll 样受体 4 激活诱导巨噬细胞同时表达 SLIT3 和 microRNA-218-2，从而抑制破骨细胞的分化。
Cell Commun Signal. 2023 Aug 18;21(1):213. doi: 10.1186/s12964-023-01226-w.
2
Always stressed but never exhausted: how stem cells in myeloid neoplasms avoid extinction in inflammatory conditions.始终处于压力之下但从不疲惫：髓系肿瘤中的干细胞如何在炎症条件下避免灭绝。
Blood. 2023 Jun 8;141(23):2797-2812. doi: 10.1182/blood.2022017152.
3
A chemorepellent inhibits local Ras activation to inhibit pseudopod formation to bias cell movement away from the chemorepellent.化学排斥物抑制局部 Ras 激活以抑制伪足形成，从而使细胞运动偏离化学排斥物。
Mol Biol Cell. 2022 Jan 1;33(1):ar9. doi: 10.1091/mbc.E20-10-0656. Epub 2021 Nov 17.
4
Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells.Slit-2/Robo-1调节CXCL12/CXCR4诱导的T细胞趋化性。
J Leukoc Biol. 2007 Sep;82(3):465-76. doi: 10.1189/jlb.1106678. Epub 2007 Jun 12.
5
Neural immunity: Friend or foe?神经免疫：是友还是敌？
J Neurovirol. 2002 Dec;8(6):474-9. doi: 10.1080/13550280290168631.
本文引用的文献
1
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome.影响黑腹果蝇幼虫表皮模式的突变：I. 第二条染色体上的合子基因座。
Wilehm Roux Arch Dev Biol. 1984 Sep;193(5):267-282. doi: 10.1007/BF00848156.
2
Chemotaxis in leukocytes.白细胞的趋化性。
Physiol Rev. 1946 Jul;26(3):319-36. doi: 10.1152/physrev.1946.26.3.319.
3
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.抗体与抗原混合物对多形核白细胞的趋化作用。
J Exp Med. 1962 Mar 1;115(3):453-66. doi: 10.1084/jem.115.3.453.
4
Role of chemotaxis in inflammation.趋化作用在炎症中的作用。
Physiol Rev. 1954 Jul;34(3):529-62. doi: 10.1152/physrev.1954.34.3.529.
5
Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.Slit蛋白：从神经元到白细胞等各类细胞的分子引导信号。
Curr Opin Genet Dev. 2002 Oct;12(5):583-91. doi: 10.1016/s0959-437x(02)00343-x.
6
Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.趋化因子SDF-1作为胚胎小脑神经元的脑膜吸引剂的作用。
Nat Neurosci. 2002 Aug;5(8):719-20. doi: 10.1038/nn881.
7
Targeting monocyte recruitment in CNS autoimmune disease.针对中枢神经系统自身免疫性疾病中的单核细胞募集
Clin Immunol. 2002 May;103(2):125-31. doi: 10.1006/clim.2001.5167.
8
Antichemokine immunotherapy for allergic diseases.用于过敏性疾病的抗趋化因子免疫疗法。
Curr Opin Allergy Clin Immunol. 2001 Dec;1(6):561-7. doi: 10.1097/00130832-200112000-00012.
9
The role of chemokines in linking innate and adaptive immunity.趋化因子在连接天然免疫与适应性免疫中的作用。
Curr Opin Immunol. 2002 Feb;14(1):129-35. doi: 10.1016/s0952-7915(01)00308-9.
10
Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.神经元迁移中的信号转导：GTP酶激活蛋白和小GTP酶Cdc42在Slit-Robo信号通路中的作用。
Cell. 2001 Oct 19;107(2):209-21. doi: 10.1016/s0092-8674(01)00530-x.
Zotero 插件