Izikson Leonid, Klein Robyn S, Luster Andrew D, Weiner Howard L
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.
Clin Immunol. 2002 May;103(2):125-31. doi: 10.1006/clim.2001.5167.
Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS). Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS.
单核细胞和巨噬细胞在多种自身免疫性炎症疾病中发挥致病作用。在实验性自身免疫性脑脊髓炎（EAE）（多发性硬化症的动物模型）中的最新研究已经确定了一种关键的趋化因子介导的单核细胞归巢至中枢神经系统（CNS）的机制。在此，我们总结了EAE中的当前研究结果，提出了靶向趋化因子轴以治疗中枢神经系统炎症性疾病的理论依据，并综述了目前可用的抑制单核细胞向中枢神经系统迁移的分子特异性疗法。
