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TGF beta/Smad signaling system and its pathologic correlates.

作者信息

Cohen M Michael

出版信息

Am J Med Genet A. 2003 Jan 1;116A(1):1-10. doi: 10.1002/ajmg.a.10750.

DOI:10.1002/ajmg.a.10750
PMID:12476444
Abstract
摘要

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TGF beta/Smad signaling system and its pathologic correlates.转化生长因子β/信号转导和转录激活因子信号系统及其病理相关性。
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The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells.转化生长因子-β/SMAD信号通路存在于人类系膜细胞中并发挥作用。
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Defective transforming growth factor beta signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2.头颈部鳞状细胞癌中转化生长因子β信号通路存在缺陷,这可由活化型Smad2表达缺失得以证实。
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NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.NEDD4-2(神经前体细胞表达,发育过程中下调4-2)通过诱导Smad2和转化生长因子-β(TGF-β)I型受体的泛素介导降解来负向调节TGF-β信号传导。
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