Korot'ko G F, Rozin D G
Biull Eksp Biol Med. 1976 Jan;81(1):6-9.
Chronic experiments were conducted on dogs with pancreatic fistulae; secretion of the pancreas (basal and stimulated by duodenal perfusion by acid solutions, albumin and its polypeptide hydrolysate) was investigated with consideration to its enzyme (amylase, trypsin, chymotrypsin) secretion. The polypeptide hydrolysate proved to stimulate the pancreatic enzymes more than pure protein. Barbamyl, chlorpromazine and amyzyl inhibited both the basal and the stimulated secretion of the pancreas. The differential character of the pancreatic enzyme secretion was most disturbed by chlorpromazine and amizyl; this served as an evidence of the substantial role of the central adrenergic and cholinergic structures in the adaptation of the pancreatic secretion to food stimuli.
对患有胰瘘的狗进行了慢性实验；研究了胰腺的分泌（基础分泌以及由酸性溶液、白蛋白及其多肽水解产物进行十二指肠灌注刺激后的分泌），并考虑了其酶（淀粉酶、胰蛋白酶、糜蛋白酶）的分泌情况。结果证明，多肽水解产物比纯蛋白质更能刺激胰腺酶的分泌。巴比妥、氯丙嗪和阿米基抑制胰腺的基础分泌和刺激分泌。氯丙嗪和阿米基对胰腺酶分泌的差异特性干扰最大；这证明了中枢肾上腺素能和胆碱能结构在胰腺分泌适应食物刺激过程中的重要作用。
