La Bella A, Lahaie R G, Sarles H, Dagorn J C
Am J Physiol. 1981 Feb;240(2):G109-13. doi: 10.1152/ajpgi.1981.240.2.G109.
Felber et al. (Lancet 2: 185-188, 1974) reported that duodenal extracts obtained from rats fed a given meal induced the specific secretion of related pancreatic enzymes. Such an observation challenges the generally accepted theory of parallel secretion of pancreatic enzymes. Although these experiments were faithfully reproduced, no induction of specific enzyme secretion could be obtained. Moreover, comparison of the secretagogue potency of different preparations of duodenal extract, both in vivo (anesthetized rat) and in vitro (pancreatic lobules), demonstrated that in the original extraction procedure most of the secretagogue activity was lost. Finally, even the fully active extract failed to induce specific enzyme secretion. It is therefore unlikely that duodenal extracts from rats fed a specific meal can induce selective secretion of the related enzyme.
费尔伯等人（《柳叶刀》2: 185 - 188，1974年）报告称，从喂食特定餐食的大鼠获取的十二指肠提取物可诱导相关胰腺酶的特异性分泌。这一观察结果对普遍接受的胰腺酶平行分泌理论提出了挑战。尽管这些实验被如实重复，但并未获得特异性酶分泌的诱导。此外，对不同十二指肠提取物制剂在体内（麻醉大鼠）和体外（胰腺小叶）的促分泌剂效力进行比较表明，在原始提取过程中，大部分促分泌剂活性丧失。最后，即使是完全活性的提取物也未能诱导特异性酶分泌。因此，喂食特定餐食的大鼠的十二指肠提取物不太可能诱导相关酶的选择性分泌。
