Aps C, Bell J A, Jenkins B S, Poole-Wilson P A, Reynolds F
Br Med J. 1976 Jan 3;1(6000):13-5. doi: 10.1136/bmj.1.6000.13.
Plasma lignocaine concentrations were measured during and after lignocaine infusions administered for suppressing ventricular dysrhythmias. Twenty-four patients with a primary diagnosis of acute myocardial infarction without gross circulatory disturbance received, after a bolus of lignocaine, either 4 mg/min for 30 minutes, 2 mg/min for two hours, then 1 mg/min thereafter or 1 mg/min throughout. The higher dose regimen produced continous therapeutic levels of lignocaine, which were achieved only after four hours by the lower dose. On the other hand, in patients who had undergone cardiac surgery and who had circulatory and heptic dysfunction the lower dose regimen achieved therapeutic levels early. The plasma half life was longer in the surgical group (P less than 0.02). The higher initial infusion rate is recommended for patients with acute myocardial infarction without gross circulatory impairment.
在输注利多卡因以抑制室性心律失常期间及之后，测定血浆利多卡因浓度。24例初步诊断为急性心肌梗死且无明显循环障碍的患者，在给予一次利多卡因推注后，分别接受以下两种给药方案：一种是先以4mg/分钟的速度输注30分钟，然后以2mg/分钟的速度输注两小时，之后以1mg/分钟的速度输注；另一种是全程以1mg/分钟的速度输注。较高剂量方案可使利多卡因维持持续的治疗浓度，而较低剂量方案在4小时后才达到该浓度。另一方面，在接受心脏手术且有循环和肝功能障碍的患者中，较低剂量方案能更早达到治疗浓度。手术组的血浆半衰期更长（P小于0.02）。对于无明显循环障碍的急性心肌梗死患者，建议采用较高的初始输注速率。
