Miller Brigitte E, Pittman Barbara, Case Doug, McQuellon Richard P
Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Gynecol Oncol. 2002 Nov;87(2):178-84. doi: 10.1006/gyno.2002.6812.
The objective of this study was to determine the health-related quality of life (QOL) of disease-free patients after therapy for gynecologic malignancies at follow-up in an outpatient clinic.
Eighty-five patients (P) completed the general Functional Assessment of Cancer Therapy (FACT-G) QOL questionnaire at least 6 months after treatment for a gynecologic malignancy. Responses were compared to 42 unmatched healthy women (H) who were seen for standard gynecologic screening exams. Statistical evaluation was done using t tests, chi(2),and Wilcoxon rank-sum tests, Spearman rank correlations, and linear regression.
The demographic data for the groups were as follows: median age P, 59 years; H, 56 years; Caucasian P, 51%; H, 56%, African American P, 49%; H, 44%, cervix cancer (n = 51, 60%), uterine cancer (n = 24, 28%), ovarian cancer (n = 10, 12%). The median time since therapy was 39 months (range 6-149 months). There were no overall differences in FACT-G scores of patients and healthy women. Cancer survivors scored slightly higher on the emotional well-being subscale (mean 20.4 vs 19.2). Among cancer patients, all scores were lowest in patients with ovarian cancer. Longer treatment time was associated with a lower physical well-being. Older patients scored higher on emotional well-being, but lower on social/family well-being. Poor education and no help at home were associated with lower functional well-being and total FACT scores. Linear regression analysis revealed significantly lower total QOL scores in patients with the following characteristics: ovarian cancer diagnosis, treatment with radiation therapy or multi-modality therapy, less than high school education, and lack of help at home.
Overall the recovery from treatment for gynecological cancer is good. Patients with ovarian cancer, prolonged therapy, poor education, and little social support have the most significant impairments in health-related quality of life and need additional support resources.
本研究的目的是确定妇科恶性肿瘤患者在门诊随访时治疗后无病生存患者的健康相关生活质量（QOL）。
85例患者（P）在接受妇科恶性肿瘤治疗至少6个月后完成了癌症治疗功能评估通用问卷（FACT-G）。将这些患者的回答与42例未匹配的健康女性（H）进行比较，这些健康女性接受了标准的妇科筛查检查。采用t检验、卡方检验、Wilcoxon秩和检验、Spearman秩相关分析和线性回归进行统计评估。
两组的人口统计学数据如下：患者组中位年龄59岁；健康女性组56岁；患者组白人占51%；健康女性组56%，患者组非裔美国人占49%；健康女性组44%，宫颈癌（n = 51，60%），子宫癌（n = 24，28%），卵巢癌（n = 10，12%）。治疗后的中位时间为39个月（范围6 - 149个月）。患者和健康女性的FACT-G评分总体上没有差异。癌症幸存者在情感幸福子量表上的得分略高（平均20.4对19.2）。在癌症患者中，卵巢癌患者的所有得分最低。治疗时间越长，身体幸福感越低。年龄较大的患者在情感幸福方面得分较高，但在社会/家庭幸福方面得分较低。教育程度低和在家中无人帮助与功能幸福感和FACT总分较低有关。线性回归分析显示，具有以下特征的患者的总QOL得分显著较低：卵巢癌诊断、接受放射治疗或多模式治疗、高中以下学历以及在家中缺乏帮助。
总体而言，妇科癌症治疗后的恢复情况良好。卵巢癌患者、治疗时间延长、教育程度低和社会支持少的患者在健康相关生活质量方面受损最严重，需要额外的支持资源。
