Eliakim Alon, Nemet Dan, Friedland Orit, Dolfin Tzipora, Regev Rivka H
Department of Pediatrics, Meir Hospital, Kfar Saba, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Perinatol. 2002 Dec;22(8):650-2. doi: 10.1038/sj.jp.7210820.
Determination of bone strength of lower extremities in very low birth weight (VLBW) premature infants with central nervous system pathology resulting in reduced unilateral spontaneous leg movements.
Quantitative ultrasound (QUS) measurements of speed of sound (SOS) of the tibiae of both legs in three VLBW premature infants with brain insult and unilateral reduced spontaneous activity. Results were compared to QUS measurements of both legs in healthy premature infants. Measurements were performed by the same investigator who was blinded to the clinical course of the participants.
Reduced spontaneous activity of one leg due to brain pathology resulted in decreased tibial SOS in the affected side. There was no difference in bone SOS between the legs of the healthy controls.
Spontaneous movements (mainly antigravity flexion and extension) are important for bone structure and mineralization in VLBW premature infants. QUS may become an important diagnostic modality for the evaluation, treatment, and follow-up of bone strength and osteopenia in this unique population.
测定极低出生体重（VLBW）且患有中枢神经系统病变导致单侧自发腿部运动减少的早产儿下肢骨强度。
对三名患有脑损伤且单侧自发活动减少的VLBW早产儿的双腿胫骨进行定量超声（QUS）声速（SOS）测量。将结果与健康早产儿双腿的QUS测量结果进行比较。测量由同一名对参与者临床过程不知情的研究人员进行。
因脑部病变导致一侧腿部自发活动减少，致使患侧胫骨SOS降低。健康对照组双腿的骨SOS无差异。
自发运动（主要是抗重力屈伸）对VLBW早产儿的骨骼结构和矿化很重要。QUS可能成为评估、治疗和随访这一特殊人群骨强度和骨质减少的重要诊断方法。
