Urdiales-Viedma Mariano, Fernandez-Rodriguez Antonio, De Haro-Muñoz Tomás, Pichardo-Pichardo Sergio
Departments of Pathology and Urology, Unidad de Anatomía Patológica, Hospital San Juan de la Cruz, Ubeda, Jaén, Spain.
Ann Diagn Pathol. 2002 Dec;6(6):381-4. doi: 10.1053/adpa.2002.36654.
A 76-year-old man presented with a tumoral lesion in his penis that had all the light microscopic and immunohistochemical features of a squamous cell carcinoma with rhabdoid phenotype. We believe that this is the fourth reported case of squamous cell carcinoma with rhabdoid features and the first one located in the penis. Rhabdoid cells were primarily located in areas with an alveolar pattern, most of them being isolated and intermixed with necrotic cells and necrotic debris. We suggest that the rhabdoid phenotype could represent a type of degeneration, or a preliminary stage before apoptosis or cell necrosis, instead of a specific differentiation. In extrarenal tumors with rhabdoid features, stage and histologic types of tumors where rhabdoid changes occur are the most important prognostic factors.
一名76岁男性阴茎出现肿瘤性病变，其具有横纹肌样表型的鳞状细胞癌的所有光镜和免疫组化特征。我们认为这是第四例报道的具有横纹肌样特征的鳞状细胞癌病例，也是首例发生于阴茎的此类病例。横纹肌样细胞主要位于呈肺泡样结构的区域，大多数为单个存在，并与坏死细胞及坏死碎片混合。我们认为横纹肌样表型可能代表一种退变类型，或凋亡或细胞坏死之前的一个初步阶段，而非一种特异性分化。在具有横纹肌样特征的肾外肿瘤中，发生横纹肌样改变的肿瘤分期及组织学类型是最重要的预后因素。
