Urdiales Viedma Mariano, Fernández Rodríguez Antonio, Romero Díaz José Angel, Madrid Gutiérrez Manuel
Unidad de Anatomía Patológica, Hospital San Juan de la Cruz, Ubeda, Jaén, España.
Arch Esp Urol. 2003 May;56(4):425-7.
To describe a squamous cell carcinoma of the penis with rhabdoid phenotype. We believe that only three squamous cell carcinomas with rhabdoid cells have been previously published and none of them was located in the penis.
A 76 year old man presented a tumoral lesión in his penis, which had all the light microscopic and immunohistochemical features of a squamous cell carcinoma with rhabdoid phenotype. Rhabdoid cells were mainly located in areas with an alveolar pattern, most of them being isolated and intermixed with necrotic cells and necrotic debris.
First case of rhabdoid squamous cell carcinoma located in the penis. We suggest that rhabdoid phenotype could represent a type of degeneration, or a preliminary stage before apoptosis or cell necrosis occurs, instead of a specific differentiation. The most important prognostic factors in extrarenal tumors with rhabdoid features are stage and histologic type of tumors.
描述一例具有横纹肌样表型的阴茎鳞状细胞癌。我们认为此前仅发表过三例伴有横纹肌样细胞的鳞状细胞癌，且均不在阴茎部位。
一名76岁男性阴茎出现肿瘤性病变，其具有横纹肌样表型鳞状细胞癌的所有光镜及免疫组化特征。横纹肌样细胞主要位于呈肺泡样结构的区域，大多为单个存在，并与坏死细胞及坏死碎片混合。
首例位于阴茎的横纹肌样鳞状细胞癌。我们认为横纹肌样表型可能代表一种退变类型，或细胞凋亡或坏死发生前的一个初步阶段，而非一种特异性分化。具有横纹肌样特征的肾外肿瘤最重要的预后因素是肿瘤分期和组织学类型。
