Omer H O, Abdel Wahab S M
Br Med J. 1976 Feb 14;1(6006):375-7. doi: 10.1136/bmj.1.6006.375.
Four children with Schistosoma mansoni infection and the nephrotic syndrome with varying degrees of renal dysfunction were found on histological examination to have amyloidosis. In one boy who had no evidence of renal failure complete clinical regression of his nephrotic syndrome and almost complete disappearance of renal amyloid deposits followed adequate treatment of his schistosomal infection. Conditions known to cause secondary amyloidosis were excluded in all four patients. Amyloidosis in association with mansoni infection is probably more common than is currently recognised. Early treatment of the infection, before renal function becomes impaired, may result in regression of the amyloidosis.
四名感染曼氏血吸虫且患有肾病综合征并伴有不同程度肾功能不全的儿童，经组织学检查发现患有淀粉样变性。在一名没有肾衰竭证据的男孩中，对其血吸虫感染进行充分治疗后，他的肾病综合征完全临床缓解，肾脏淀粉样沉积物几乎完全消失。所有四名患者均排除了已知会导致继发性淀粉样变性的疾病。与曼氏血吸虫感染相关的淀粉样变性可能比目前所认识到的更为常见。在肾功能受损之前尽早治疗感染，可能会使淀粉样变性消退。
