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手性2,3-二氢-4-吡啶酮的合成应用

Synthetic applications of chiral 2,3-dihydro-4-pyridones.

作者信息

Joseph Sajan, Comins Daniel L

机构信息

Eli Lilly & Company, Lilly Corporate Center Drop Code 0528, Indianapolis, IN 46285, USA.

出版信息

Curr Opin Drug Discov Devel. 2002 Nov;5(6):870-80.

Abstract

During the last decade, 2,3-dihydro-4-pyridones have become important intermediates for the synthesis of various alkaloids and biologically active compounds. The versatility of these heterocyclic building blocks has been demonstrated by the synthesis of several complex natural products. This review will cover recent work on the synthesis of substituted dihydropyridones, and their application in the synthesis of complex molecules.

摘要

在过去十年中,2,3 - 二氢 - 4 - 吡啶酮已成为合成各种生物碱和生物活性化合物的重要中间体。这些杂环结构单元的多功能性已通过几种复杂天然产物的合成得到证明。本综述将涵盖取代二氢吡啶酮合成的近期工作及其在复杂分子合成中的应用。

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