Department of Chemistry, Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, USA.
J Am Chem Soc. 2010 Nov 10;132(44):15512-3. doi: 10.1021/ja107329k.
Cyclic enaminones were synthesized in high yields from amino acids in two steps via Wolff rearrangement. The cyclization represents a rare 6-exo-dig cyclization involving a ketene as an electrophile. No racemization was observed during this reaction.
环烯胺酮可由氨基酸经两步反应、通过沃尔夫重排高产率合成。环化反应是一种罕见的 6-endo-dig 环化反应,涉及作为亲电试剂的烯酮。在该反应过程中未观察到外消旋化。