Ferrero Simone, Colombo Barbara M, Arena Elisa, Fenini Fabio, Ragni Nicola
Dipartimento di Ginecologia e Ostetricia Ospedale San Martino Padiglione 1 Largo R. Benzi, 10 16132 Genova.
Ital Heart J Suppl. 2002 Oct;3(10):993-1002.
The major concern about the administration of antiarrhythmic drugs during pregnancy is related to their effect on fetal well-being. Even if teratogenic risks are higher during organogenesis in the first 8 weeks of pregnancy, after this period undesirable effects may include depression of uterine blood flow, interference with fetal growth and development, and interference with labor and delivery. Most drugs are secreted in the mother's milk, a fact that raises concern about the nursing infants. In this report we review the fetal risks related to the management of maternal arrhythmias during pregnancy showing that most patients can be treated with an excellent result for their babies.
孕期使用抗心律失常药物的主要担忧与其对胎儿健康的影响有关。即使在妊娠前8周器官形成期致畸风险较高,但在此之后,不良影响可能包括子宫血流减少、干扰胎儿生长发育以及干扰分娩过程。大多数药物会分泌到母乳中,这一事实引发了对哺乳期婴儿的担忧。在本报告中,我们回顾了孕期母亲心律失常管理相关的胎儿风险,结果表明大多数患者接受治疗后对其婴儿有良好效果。