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[妊娠期心律失常。如何治疗以及何时治疗?]

[Arrhythmias in pregnancy. How and when to treat?].

作者信息

Flores Jorge R Gómez, Márquez Manlio F

机构信息

Servicio de Electrocardiografía, Instituto Nacional de Cardiología lgnacio Chávez, Tlalpan, Ciudad de México DF.

出版信息

Arch Cardiol Mex. 2007 Apr-Jun;77 Suppl 2:S2-24-S2-31.

Abstract

Cardiac arrhythmias can develop during pregnancy. The risk of arrhythmias is relatively higher during labor and delivery. Potential factors that can promote arrhythmias in pregnancy or during labor and delivery, include the direct cardiac electrophysiological effects of hormones, changes in autonomic tone, hemodynamic perturbations, hypokalemia, and underlying heart disease. In this review, the basis for treatment of supraventricular and ventricular tachycardias are described. No drug therapy is usually needed for the management of supraventricular or ventricular premature beats, but potential stimulants, such as smoking, caffeine, and alcohol should be eliminated. In paroxysmal supraventricular tachycardia, vagal stimulation maneuvers should be attempted first. In pregnant women with atrial fibrillation, the goal of treatment is conversion to sinus rhythm by electrical cardioversion. Rate control can be achieved by a cardioselective beta-adrenergic blocker drug and/ or digoxin. Ventricular arrhythmias may occur in the pregnant women, specially when cardiomyopathy, congenital heart disease, valvular heart disease, or mitral valve prolapse exists. Electrical cardioversion or treatment with sotalol may be used (amiodarone is not safe for the fetus). Finally, in women with congenital long QT syndrome, beta-blocker therapy must be continued during pregnancy and postpartum period.

摘要

心律失常可在孕期发生。分娩期间心律失常的风险相对较高。在孕期或分娩期间可促发心律失常的潜在因素包括激素对心脏的直接电生理作用、自主神经张力的变化、血流动力学紊乱、低钾血症以及潜在的心脏病。在这篇综述中,描述了室上性和室性心动过速的治疗依据。室上性或室性早搏的管理通常无需药物治疗,但应避免潜在的刺激因素,如吸烟、咖啡因和酒精。对于阵发性室上性心动过速,应首先尝试迷走神经刺激手法。对于患有房颤的孕妇,治疗目标是通过电复律转为窦性心律。心率控制可通过心脏选择性β肾上腺素能阻滞剂药物和/或地高辛实现。室性心律失常可能发生在孕妇中,特别是存在心肌病、先天性心脏病、瓣膜性心脏病或二尖瓣脱垂时。可采用电复律或索他洛尔治疗(胺碘酮对胎儿不安全)。最后,对于患有先天性长QT综合征的女性,孕期和产后必须持续进行β受体阻滞剂治疗。

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