Alves Fàbio A, Perez Daniel E C, Almeida Osley P, Lopes Márcio A, Kowalski Luiz P
Hospital do Câncer-Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia, R. Prof. Antônio Prudente, 211, CEP 01509-900, São Paulo, Brazil.
Arch Otolaryngol Head Neck Surg. 2002 Dec;128(12):1400-3. doi: 10.1001/archotol.128.12.1400.
The submandibular gland is involved in only 5% to 10% of the salivary gland tumors, and pleomorphic adenoma (PA) is the most common tumor affecting it. This study describes the clinicopathological features and immunohistochemical expression of Ki-67 and p53 in 60 cases of submandibular salivary gland PAs. Most of the patients were in the third and fifth decades of life and 37 (62%) of them were women. Tumor sizes varied from 1 to 10 cm and the mean time between symptom onset and treatment was 52 months. Only 1 patient experienced local recurrence, 3 years after treatment. Histologically, most tumors consisted chiefly in a chondromyxoid stroma. Stroma-rich PAs were larger than stroma-poor ones (P<.02). All PAs were found negative for Ki-67 and p53. These results show that PAs of the submandibular gland are histologically similar to PAs of other salivary glands, and that they have a low proliferative rate and a good prognosis.
下颌下腺仅累及5%至10%的涎腺肿瘤，多形性腺瘤（PA）是最常累及该腺体的肿瘤。本研究描述了60例下颌下涎腺多形性腺瘤的临床病理特征以及Ki-67和p53的免疫组化表达。大多数患者年龄在第三和第五个十年，其中37例（62%）为女性。肿瘤大小从1至10厘米不等，症状出现至治疗的平均时间为52个月。仅1例患者在治疗后3年出现局部复发。组织学上，大多数肿瘤主要由软骨黏液样间质组成。富含间质的多形性腺瘤比间质少的更大（P<0.02）。所有多形性腺瘤的Ki-67和p53均为阴性。这些结果表明，下颌下腺多形性腺瘤在组织学上与其他涎腺的多形性腺瘤相似，且增殖率低，预后良好。
