多肌炎和皮肌炎的临床与病理研究：83例报告
[Clinical and pathological investigation of polymyositis and dermatomyositis: report of 83 cases].
作者信息
Li Qiang, Lu Bing-Xun, Zhou Liang, An Sheng-Li
机构信息
Department of Neurology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2002 Dec;22(12):1139-40.
OBJECTIVE
To study the clinical and pathological characteristics and treatment of polymyositis (PM) and dermatomyositis (DM).
METHODS
Eighty-three DM/PM cases were reviewed and analyzed.
RESULTS
The main clinical presentations of PM/DM included amyosthenia, muscular tenderness, elevation of serum enzymes, accompanied by abnormal electromyography and muscular pathology. A total efficacy rate of 86.7% was achieved after treatment with corticosteroid and immuno- depressants.
CONCLUSION
The different clinical and pathological presentations of various types of PM/DM suggest different pathogenesis between DM and PM. Nerve damage is a part of the systemic damages due to the disease, the prognosis of which is related to its classification and then timing of the treatment. Early effective treatment can improve the prognosis.
目的
研究多发性肌炎（PM）和皮肌炎（DM）的临床及病理特征与治疗方法。
方法
回顾并分析83例DM/PM病例。
结果
PM/DM的主要临床表现包括肌无力、肌肉压痛、血清酶升高，伴有肌电图异常及肌肉病理改变。使用糖皮质激素和免疫抑制剂治疗后总有效率达86.7%。
结论
不同类型的PM/DM其临床和病理表现各异，提示DM与PM发病机制不同。神经损伤是该疾病所致全身损害的一部分，其预后与其分类及治疗时机有关。早期有效治疗可改善预后。
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