Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Neurol India. 2010 Jan-Feb;58(1):58-61. doi: 10.4103/0028-3886.60398.
Idiopathic inflammatory myopathies, dermatomyositis (DM) and polymyositis (PM) are rare but are potentially treatable.
To compare the effect of early and late treatment in patients with PM and DM.
The study included all the adult patients with definite diagnosis of PM or DM treated for at least 12 months. The patients were divided into two groups: Early Group - treatment within three months and Late Group - treatment after three months. The number of patients with positive therapeutic response, remission in less than one year and the mean time elapsed for reaching the remission were assessed and compared between the two groups. Chi-square test, Fisher's exact test, t-test and Pearson correlation test were used for data analysis.
The analysis included 65 patients, 42 with DM and 23 with PM. Late Group included 24 patients (seven PM and 17 DM), while Early Group included 41 patients (16 PM and 25 DM). Positive therapeutic response, remission rate within one year was higher in Early Group (80% vs. 46%, P: 0.004). The mean time needed to achieve remission was much less with early treatment (5.5 vs. 11.9 months, P: 0.003). The relapse rate was also lower in Early Group (5% vs. 25%, P < 0.02). The comparison of treatment outcomes showed the same results in both PM and DM, but it was statistically significant in patients with DM.
Early treatment in patients with PM and DM is associated with higher remission rates, shorter treatment period and low complication rates.
特发性炎性肌病、皮肌炎（DM）和多发性肌炎（PM）较为罕见，但具有潜在可治性。
比较 PM 和 DM 患者早期和晚期治疗的效果。
本研究纳入了所有接受至少 12 个月治疗的明确诊断为 PM 或 DM 的成年患者。将患者分为两组：早期组-治疗在三个月内；晚期组-治疗在三个月后。评估并比较两组患者的治疗反应阳性、一年内缓解和达到缓解的平均时间。采用卡方检验、Fisher 确切检验、t 检验和 Pearson 相关检验进行数据分析。
分析纳入 65 例患者，其中 42 例为 DM，23 例为 PM。晚期组包括 24 例（7 例 PM 和 17 例 DM），而早期组包括 41 例（16 例 PM 和 25 例 DM）。早期组的治疗反应阳性率和一年内缓解率更高（80%比 46%，P：0.004）。早期治疗达到缓解所需的平均时间更短（5.5 比 11.9 个月，P：0.003）。早期组的复发率也较低（5%比 25%，P < 0.02）。治疗结果比较在 PM 和 DM 患者中均显示出相同的结果，但在 DM 患者中具有统计学意义。
PM 和 DM 患者的早期治疗与更高的缓解率、更短的治疗期和更低的并发症发生率相关。
