Yang P, Cerhan J R, Vierkant R A, Olson J E, Vachon C M, Limburg P J, Parker A S, Anderson K E, Sellers T A
Mayo Clinic Cancer Center, Rochester, MN 55905, USA.
Am J Epidemiol. 2002 Dec 15;156(12):1114-22. doi: 10.1093/aje/kwf153.
In a prospective cohort of 41,836 Iowa women aged 55-69 years with 13 years of follow-up from 1986 through 1998, the authors examined the association between cigarette smoking history and three common histologic subtypes of lung cancer (123 small cell, 115 squamous cell, and 234 adenocarcinoma). Using Cox proportional hazards and additive Poisson regression analysis, they estimated four epidemiologic measures of effect: age-adjusted incidence rate, relative risk, excess risk (or risk difference), and population attributable risk. Of the three major lung cancer subtypes, the excess risk for heavy smokers compared with never smokers was higher for adenocarcinoma (excess risk = 206) than for squamous cell (excess risk = 122) and small cell (excess risk = 104) carcinomas. Adenocarcinoma of the lung is more strongly associated with tobacco smoke exposure than previously recognized.
在一个前瞻性队列研究中，研究对象为41836名年龄在55至69岁之间的爱荷华州女性，随访时间从1986年至1998年共13年。作者研究了吸烟史与肺癌三种常见组织学亚型（123例小细胞癌、115例鳞状细胞癌和234例腺癌）之间的关联。通过Cox比例风险模型和加法泊松回归分析，他们估计了四种流行病学效应指标：年龄调整发病率、相对风险、超额风险（或风险差值）和人群归因风险。在三种主要肺癌亚型中，与从不吸烟者相比，重度吸烟者患腺癌的超额风险（超额风险 = 206）高于鳞状细胞癌（超额风险 = 122）和小细胞癌（超额风险 = 104）。肺癌腺癌与烟草烟雾暴露的关联比之前认为的更强。
