不同骨骼疾病中游离和肽结合胶原蛋白交联物排泄情况的评估
Evaluation of free and peptide bound collagen crosslink excretion in different skeletal diseases.
作者信息
Müller A, Jakob K, Hein G E
机构信息
Department of Internal Medicine IV, Rheumatology and Osteology, University of Jena, 07740 Jena, Germany.
出版信息
Ann Rheum Dis. 2003 Jan;62(1):65-7. doi: 10.1136/ard.62.1.65.
OBJECTIVE
To investigate urinary fractions of free and peptide forms of collagen crosslinks in patients with rheumatoid arthritis (n=50), osteoarthrosis (n=38), psoriatic arthritis (n=38) and in healthy volunteers (33 adults, 17 children).
METHODS
Pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by high performance liquid chromatography.
RESULTS
In rheumatoid arthritis (RA) all fractions of PYD and DPD were significantly raised compared with osteoarthritis, psoriatic arthritis, and healthy controls. PYD and DPD correlated with disease activity in RA. In RA the collagen degradation resulted in primarily peptide bound forms.
CONCLUSION
The correlation between total peptide bound or free collagen crosslinks in different chronic joint diseases varies; however, this variation does not allow for a reliable differentiation between inflammatory and degenerative joint diseases.
目的
研究类风湿关节炎患者（n = 50）、骨关节炎患者（n = 38）、银屑病关节炎患者（n = 38）以及健康志愿者（33名成年人，17名儿童）尿液中游离和肽形式的胶原蛋白交联物成分。
方法
采用高效液相色谱法测定吡啶啉（PYD）和脱氧吡啶啉（DPD）。
结果
与骨关节炎、银屑病关节炎及健康对照相比，类风湿关节炎（RA）患者中PYD和DPD的所有成分均显著升高。PYD和DPD与RA疾病活动相关。在RA中，胶原蛋白降解主要产生肽结合形式。
结论
不同慢性关节疾病中总肽结合或游离胶原蛋白交联物之间的相关性各不相同；然而，这种差异无法可靠地区分炎症性和退行性关节疾病。
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