Nor Hashimah Abu Mansor Matardiah, Sakthiswary Rajalingham, Shaharir Syahrul Sazliyana, Wahab Asrul
Department of Internal Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.
Arch Rheumatol. 2019 Apr 22;34(4):387-394. doi: 10.5606/ArchRheumatol.2019.7243. eCollection 2019 Dec.
This study aims to compare the serum pyridinoline (Pyd) levels between rheumatoid arthritis (RA) patients and healthy controls and to determine the correlation of serum Pyd levels with radiographic joint erosions.
Serum samples were obtained from 48 patients with RA (9 males, 39 females; mean age 60.5 years; range 54 to 64 years) and 48 healthy controls (9 males, 39 females; mean age 57.5 years; range, 47 to 65 years). The enzyme-linked immunosorbent assay method was used for quantitative analysis of serum Pyd. Besides, all RA patients were assessed for joint damage based on modified Sharp score, disease activity based on disease activity score in 28 joints and functional capacity based on health assessment questionnaire-disability index.
The median serum Pyd levels were significantly higher among the RA patients (110.20 ng/mL [92.30-120.64]) compared to the controls (98.22 ng/mL [85.54-111.41]); p<0.05. RA patients with erosive disease had significantly higher serum Pyd levels (p=0.024). There was a significant positive correlation between serum Pyd levels and joint erosion score (r=0.285, p=0.049). The serum Pyd levels had no demonstrable association with disease activity or functional capacity. Steroid therapy did not appear to influence the levels of serum Pyd.
Rheumatoid arthritis patients had significantly higher levels of serum Pyd compared to healthy controls. The serum Pyd levels had significant correlation with radiographic joint erosions which reflected disease damage.
本研究旨在比较类风湿关节炎（RA）患者与健康对照者的血清吡啶啉（Pyd）水平，并确定血清Pyd水平与关节影像学侵蚀的相关性。
采集48例RA患者（9例男性，39例女性；平均年龄60.5岁；范围54至64岁）和48例健康对照者（9例男性，39例女性；平均年龄57.5岁；范围47至65岁）的血清样本。采用酶联免疫吸附测定法对血清Pyd进行定量分析。此外，所有RA患者均根据改良Sharp评分评估关节损伤，根据28个关节的疾病活动评分评估疾病活动度，根据健康评估问卷残疾指数评估功能能力。
与对照组（98.22 ng/mL [85.54 - 111.41]）相比，RA患者的血清Pyd水平中位数显著更高（110.20 ng/mL [92.30 - 120.64]）；p<0.05。有侵蚀性疾病的RA患者血清Pyd水平显著更高（p = 0.024）。血清Pyd水平与关节侵蚀评分之间存在显著正相关（r = 0.285，p = 0.049）。血清Pyd水平与疾病活动度或功能能力无明显关联。类固醇治疗似乎不影响血清Pyd水平。
与健康对照者相比，类风湿关节炎患者的血清Pyd水平显著更高。血清Pyd水平与反映疾病损伤的关节影像学侵蚀显著相关。
