Antzelevitch C, Brugada P, Brugada J, Brugada R, Shimizu W, Gussak I, Perez Riera A R
Masonic Medical Research Laboratory, Utica, NY 13501, USA.
Circ Res. 2002 Dec 13;91(12):1114-8. doi: 10.1161/01.res.0000046046.53721.90.
The Brugada syndrome has gained wide recognition throughout the world and today is believed to be responsible for 4% to 12% of all sudden deaths and approximately 20% of deaths in patients with structurally normal hearts. The incidence of the disease is on the order of 5 per 10 000 inhabitants and, apart from accidents, is the leading cause of death of men under the age of 50 in regions of the world where the inherited syndrome is endemic. This minireview briefly summarizes the progress made over the past decade in our understanding of the clinical, genetic, cellular, ionic, and molecular aspects of this disease.
Brugada综合征已在全球范围内得到广泛认可，如今被认为占所有猝死病例的4%至12%，在心脏结构正常的患者中约占死亡病例的20%。该疾病的发病率约为每10000名居民中有5例，除意外事故外，在该遗传性综合征流行的世界地区，它是50岁以下男性的主要死因。本综述简要总结了过去十年我们在该疾病的临床、遗传、细胞、离子和分子方面的认识进展。
