Dumortier Jérĵme, Czyglik Olivier, Poncet Gilles, Blanchet Marie-Cécile, Boucaud Catherine, Henry Luc, Boillot Olivier
Unité de Transplantation Hépatique, Hôpital Edouard Herriot, 69437 Lyon Cedex 03, France.
Am J Transplant. 2002 Nov;2(10):934-8. doi: 10.1034/j.1600-6143.2002.21009.x.
Portal vein thrombosis (PVT) has been seen as an obstacle to orthotopic liver transplantation (OLT), but recent data suggest that favorable results may be achieved in this group of patients. The aim of this study was to analyze the incidence, management, and survival of patients with PVT undergoing primary OLT with thrombectomy. Between October 1990 and August 2000, 468 liver transplantations were performed in our center and portal vein thrombosis was present in 38 patients (8.1%). Preoperative diagnosis, extension, intraoperative management, postoperative recurrence of portal vein thrombosis, and 1-year actuarial survival rates were retrospectively studied. Preoperative diagnosis was made in 17 cases (44.7%). In all patients, portal flow was restored after portal vein thrombectomy, followed by usual end-to-end portal anastomosis. All patients received preventive low-weight heparin from day 2 to hospital discharge, and then aspirin. Rethrombosis was observed in one patient with extended splanchnic thrombus. The 1-year actuarial patient survival rate was 83.7%, and did not significantly differ from the patients without portal vein thrombosis (86.7%). Our results suggest that portal vein thrombosis is often partial and thus difficult to diagnose preoperatively: it can be managed successfully during surgery by thrombectomy, except when there is complete splanchnic veins thrombosis; and it did not affect 1-year survival.
门静脉血栓形成(PVT)曾被视为原位肝移植(OLT)的一个障碍,但最近的数据表明,这类患者可能会取得良好的结果。本研究的目的是分析接受原发性OLT并进行血栓切除术的PVT患者的发病率、治疗方法和生存率。1990年10月至2000年8月期间,我们中心共进行了468例肝移植手术,其中38例(8.1%)存在门静脉血栓形成。对术前诊断、血栓范围、术中处理、门静脉血栓形成的术后复发情况以及1年实际生存率进行了回顾性研究。17例(44.7%)患者术前得到诊断。所有患者在门静脉血栓切除术后恢复了门静脉血流,随后进行了常规的门静脉端端吻合。所有患者从术后第2天至出院均接受预防性低剂量肝素治疗,出院后服用阿司匹林。1例伴有广泛内脏血栓的患者出现了再血栓形成。1年实际患者生存率为83.7%,与无门静脉血栓形成的患者(86.7%)相比无显著差异。我们的结果表明,门静脉血栓形成通常是部分性的,因此术前难以诊断:除了存在完全性内脏静脉血栓形成的情况外,手术中通过血栓切除术可成功处理;并且它不影响1年生存率。