Kretzschmar Titus, von Rüden Thomas
MorphoSys AG, Lena-Christ-Strasse 48, D-82152, Martinsried, Germany.
Curr Opin Biotechnol. 2002 Dec;13(6):598-602. doi: 10.1016/s0958-1669(02)00380-4.
Phage display has proven to be a robust and convenient technology for the selection of high-quality human antibodies from diverse libraries. Besides enabling the identification of antibodies in a fast, high-throughput mode, which allows comprehensive protein expression analyses, phage display has been used to identify a fully human therapeutic antibody presently undergoing the regulatory process for market approval.
噬菌体展示已被证明是一种从各种文库中筛选高质量人源抗体的强大且便捷的技术。除了能够以快速、高通量的模式鉴定抗体,从而实现全面的蛋白质表达分析外,噬菌体展示还被用于鉴定一种目前正处于监管审批流程以获得市场批准的全人源治疗性抗体。