Alsen C, Béress L, Fischer K, Proppe D, Reinberg T, Sattler R W
Naunyn Schmiedebergs Arch Pharmacol. 1976 Oct;295(1):55-62. doi: 10.1007/BF00509773.
The cardiac activity of toxin II, a basic polypeptide (m.w.: 4770) from the sea anemone Anemonia sulcata, was investigated in isolated electrically driven guinea-pig and rat auricles, Langendorff heart preparations of guinea-pigs and cat heart-lung preparations. Low concentrations of toxin II (2-100 nM) evoked a dose-dependent positive inotropic effect in the three different heart muscle preparations investigated. Higher concentrations of toxin II produced toxic symptoms like contracture and arrhythmia in auricles and atria (about 25 nM). In isolated cat hearts high toxin II concentrations (about 160 nM) caused unusual toxic symptoms such as long periods of ventricular fibrillation alternating with periods of normal cardiac activity. In rat and guinea-pig auricles as well as in Langendorff hearts of guinea-pigs the extent and rate of the positive inotropic effect induced by toxin II depended on the extracellular calcium concentration (0.45 to 2.7 mM). Toxin II did not alter the heart rate in spontaneously beating isolated cat hearts. In electrically driven guinea-pig auricles, the rate of the inotropic effect induced by toxin II was accelerated by increasing stimulation frequencies. Toxin II did not change the coronary flow in Langendorff heart preparations of guinea-pigs.
对来自沟迎风海葵的一种碱性多肽（分子量：4770）毒素II的心脏活性，在分离的电驱动豚鼠和大鼠心房、豚鼠的Langendorff心脏标本以及猫心肺标本中进行了研究。低浓度的毒素II（2 - 100 nM）在所研究的三种不同心肌标本中引起剂量依赖性的正性肌力作用。较高浓度的毒素II（约25 nM）在心房和心耳中产生诸如挛缩和心律失常等毒性症状。在分离的猫心脏中，高浓度的毒素II（约160 nM）引起异常的毒性症状，如长时间的心室颤动与正常心脏活动期交替出现。在大鼠和豚鼠心房以及豚鼠的Langendorff心脏中，毒素II诱导的正性肌力作用的程度和速率取决于细胞外钙浓度（0.45至2.7 mM）。毒素II不会改变自发搏动的分离猫心脏的心率。在电驱动的豚鼠心房中，毒素II诱导的正性肌力作用速率会随着刺激频率增加而加快。毒素II不会改变豚鼠Langendorff心脏标本中的冠状动脉血流量。
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