Izawa Hikaru, Souma Itsurou, Fukuchi Nariaki, Yoshida Tetsuya, Ebisui Chikara, Sakita Isao, Kanai Toshio, Fujimoto Takayoshi
Dept. of Surgery, Hyogo Prefectural Nishinomiya Hospital.
Gan To Kagaku Ryoho. 2002 Nov;29(12):2350-3.
Anorectal malignant melanoma is relatively rare and its prognosis is very poor because of distant metastasis via the blood or lymphatic vessels. This paper reports a case of liver metastasis from anorectal malignant melanoma treated by chemoembolization. A 68-year-old man was admitted to our hospital because abdominal enhanced computed tomography revealed multiple liver metastases. Angiography also revealed metastasis, so a chemoembolization with nedaplatin was performed. Two months later some lesions fell into necrosis but new ones appeared, and the same treatment was performed another three times. Accessory vessels from the inferior diaphragma artery developed and prevented these treatments. The patient died from the progress of metastases to the liver, bone and skin three years and two months after the operation, or one year and three months after the liver recurrence. The chemoembolization showed some effects on liver metastases from malignant melanoma, but they were temporary.
肛管恶性黑色素瘤相对罕见，因其可通过血液或淋巴管发生远处转移，故预后很差。本文报道1例经化疗栓塞治疗的肛管恶性黑色素瘤肝转移病例。一名68岁男性因腹部增强CT显示多发肝转移而入院。血管造影也显示有转移，因此对其进行了奈达铂化疗栓塞。两个月后，一些病灶出现坏死，但又有新病灶出现，遂又进行了3次同样的治疗。来自膈下动脉的副血管形成，阻碍了这些治疗。患者在术后三年零两个月或肝复发后一年零三个月死于肝、骨和皮肤转移进展。化疗栓塞对恶性黑色素瘤肝转移有一定效果，但为暂时效果。
