Berger M, Baumhoff E, Gries F A
Dtsch Med Wochenschr. 1976 Feb 27;101(9):307-11. doi: 10.1055/s-0028-1104080.
In a study extending over five years 35 of 70 excessively overweight patients with subclinical diabetes mellitus who had not significantly changed their weight, demonstrated a further deterioration in glucose tolerance, and manifest diabetes occurred in ten. In the remaining 35 patients who had achieved 20% weight reduction from the initial level glucose tolerance had become normal. The two groups were similar as to age, initial weight, and original degree of glucose intolerance. There was a significant correlation between loss of weight and increased glucose tolerance. No such correlation occurred with subgroups of patients whose initial overweight was more than +100 relative percentage and who had been over 50 years old at the start of the study.
在一项为期五年的研究中，70名超重且患有亚临床糖尿病但体重未显著变化的患者中，35人体糖耐量进一步恶化，10人出现显性糖尿病。其余35名体重从初始水平减轻20%的患者，其糖耐量已恢复正常。两组在年龄、初始体重和原始糖耐量异常程度方面相似。体重减轻与糖耐量增加之间存在显著相关性。对于初始超重超过相对百分比+100且在研究开始时年龄超过50岁的患者亚组，未出现这种相关性。
