Toeller M, Gries F A, Shleppinghoff B, Berger M, Dannehl K
Dtsch Med Wochenschr. 1979 Oct 26;104(43):1513-7. doi: 10.1055/s-0028-1129133.
A long-term study of 63 extremely obese persons with disturbed glucose tolerance showed a further deterioration of glucose tolerance over 10 years. In 9 out of 23 patients manifest diabetes mellitus developed despite partial weight reduction (greater than or equal to 10% of the initial weight excess). Out of 14 patients who did not lose weight during this time even 11 developed manifestations of diabetes. All patients who were in different weight groups at the 5- and 10-year follow-up showed a deterioration in glucose tolerance after 10 years. In the individual groups there were only minimal differences in other characteristics apart from the different weight behaviour.
一项针对63名糖耐量受损的极度肥胖者的长期研究表明，糖耐量在10年期间进一步恶化。在23名患者中，尽管体重部分减轻（大于或等于初始超重体重的10%），仍有9人发展为显性糖尿病。在这段时间内体重未减轻的14名患者中，甚至有11人出现了糖尿病症状。在5年和10年随访时处于不同体重组的所有患者，在10年后糖耐量均出现恶化。除了不同的体重变化情况外，各体重组在其他特征方面只有极小的差异。
