Morita Keisuke, Koga Tetsuya, Moroi Yoichi, Urabe Kazunori, Furue Masutaka
Department of Dermatology, Graduate School of Medical Sciences, Fukuoka, Japan.
J Dermatol. 2002 Nov;29(11):709-12. doi: 10.1111/j.1346-8138.2002.tb00207.x.
Olopatadine hydrochloride is one of the second-generation nonsedating antihistamines that are used for treating allergic disorders such as urticaria, rhinitis, and atopic dermatitis. We examined the inhibitory effects of this drug on the flare and wheal responses induced by histamine iontophoresis at 30, 60, and 90 min after oral administration in a double-blind, cross-over, and placebo-controlled study. Olopatadine hydrochloride significantly inhibited the histamine-induced flare and wheal responses as early as 60 min after oral administration when compared with placebo. Significant inihibitory effects of olopatadine hydrochloride on the itch responses were seen at 90 min after administration. Thus, olopatadine hydrochloride exhibited a very rapid and potent antihistamine effect on the histamine-induced skin responses.
盐酸奥洛他定是第二代非镇静性抗组胺药之一，用于治疗过敏性疾病，如荨麻疹、鼻炎和特应性皮炎。在一项双盲、交叉、安慰剂对照研究中，我们检测了该药物在口服给药后30、60和90分钟对组胺离子导入诱发的风团和潮红反应的抑制作用。与安慰剂相比，盐酸奥洛他定在口服给药后60分钟时就显著抑制了组胺诱发的风团和潮红反应。给药后90分钟时观察到盐酸奥洛他定对瘙痒反应有显著抑制作用。因此，盐酸奥洛他定对组胺诱发的皮肤反应表现出非常迅速且强效的抗组胺作用。
