Bachrach Gilad, Leizerovici-Zigmond M, Zlotkin A, Naor R, Steinberg D
Department of Oral Biology, The Hebrew University - Hadassah School of Dental Medicine, Jerusalem, Israel.
Lett Appl Microbiol. 2003;36(1):50-3. doi: 10.1046/j.1472-765x.2003.01262.x.
To detect bacteriophages for Gram-positive oral pathogens in human saliva.
Saliva samples from 31 donors were screened for the presence of bacteriophages for Streptococcus sobrinus, Streptococcus mutans, Streptococcus salivarius, Actinomyces viscosus and Enterococcus faecalis. Bacteriophages for Enterococcus faecalis were found in seven samples. Enterococcus faecalis phages were still present in saliva re-collected from one donor one month, and one year after initial saliva collection.
The presence and stability of the Enterococcus faecalis bacteriophages in human saliva suggests a possible role of these bacteriophages in the oral ecosystem.
Phage therapy as a way to control oral bacteria might be considered.
检测人类唾液中革兰氏阳性口腔病原体的噬菌体。
对31名捐赠者的唾液样本进行筛选，以检测是否存在针对远缘链球菌、变形链球菌、唾液链球菌、粘性放线菌和粪肠球菌的噬菌体。在7个样本中发现了粪肠球菌的噬菌体。从一名捐赠者处首次采集唾液后1个月和1年后重新采集的唾液中仍存在粪肠球菌噬菌体。
粪肠球菌噬菌体在人类唾液中的存在及其稳定性表明这些噬菌体在口腔生态系统中可能发挥作用。
可以考虑将噬菌体疗法作为一种控制口腔细菌的方法。
