秋水仙碱对大鼠、小鼠、仓鼠和豚鼠微管蛋白聚合的影响。
Effect of colchicine on polymerization of tubulin from rats, mice, hamsters and guinea-pigs.
作者信息
Fitzgerald T J, Mayfield D G
出版信息
Experientia. 1976 Jan 15;32(1):83-4. doi: 10.1007/BF01932636.
PMID:1248602
Abstract
Colchicine-inhibition of polymerization of tulbulin from rats, mice, golden hamsters and guinea-pigs was studied to determine if species differences in tubulin sensitivity to colchicine might parallel species variation in colchicine toxicity. It was found that polymerization of tubulin is nearly equally sensitive to colchicine in all four species.
摘要
研究了秋水仙碱对大鼠、小鼠、金黄仓鼠和豚鼠微管蛋白聚合的抑制作用，以确定微管蛋白对秋水仙碱的敏感性种间差异是否与秋水仙碱毒性的种间差异平行。结果发现，在所有这四个物种中，微管蛋白的聚合对秋水仙碱几乎同样敏感。
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