Gaynes Bradley N, Burns Barbara J, Tweed Dan L, Erickson Pennifer
Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, Chapel Hill, North Carolina 27599-7160, USA.
J Nerv Ment Dis. 2002 Dec;190(12):799-806. doi: 10.1097/00005053-200212000-00001.
Chronic medical conditions drastically affect the lives of those afflicted, leading to pain, disability, and disruption. Comorbid depression can exacerbate the effects of medical illness and may be an independent source of suffering and disability. Data from the Epidemiological Follow-Up Study (NHEFS) of the first National Health and Nutrition Examination Survey (NHANES I) are used to examine the manner in which depression and comorbid medical conditions interact to affect health-related quality of life (HRQOL). The findings suggest a) that the effects of depression are comparable with those of arthritis, diabetes, and hypertension; and b) that depression and chronic medical illnesses interact to amplify the effects of the medical illness. The data also support the merit of adopting a multidimensional approach to HRQOL rather than treating it unidimensionally.
慢性疾病严重影响患者的生活，导致疼痛、残疾和生活紊乱。合并的抑郁症会加剧疾病的影响，可能是痛苦和残疾的独立来源。首次全国健康和营养检查调查（NHANES I）的流行病学随访研究（NHEFS）数据被用于研究抑郁症与合并的慢性病如何相互作用以影响健康相关生活质量（HRQOL）。研究结果表明：a）抑郁症的影响与关节炎、糖尿病和高血压的影响相当；b）抑郁症和慢性疾病相互作用会放大疾病的影响。这些数据还支持采用多维方法来评估健康相关生活质量，而不是单维评估的价值。
